نتایج جستجو برای: Spasmolytic

تعداد نتایج: 481  

Journal: :The Biochemical journal 1988
M E Baker

are oestrogen-dependent (Katzenellenbogen, 1980; McGuire, 1980). The MCF-7 cell line (Lippman & Bolan, 1975), a human breast cancer cell line, has been especially useful for understanding the mechanism of action of oestrogen. The pS2 protein (Mr 6500) is an abundant oestrogen-induced protein secreted by MCF-7 cells and found in breast tumour tissue (Masiokowski et al., 1982; Jakowlew et al., 19...

2016
A. Esaiyas Y. Mekonnen T. Tolessa

Background: Alchemilla abyssinica is a plant widely used in traditional medicine. Its wide use among the community plus already established scientific evidences for medicinal values of other Alchemilla species provided good ground for this investigation. Methods: In this research, CHCl3/EtoAc 1:1 extract of dried aerial parts of Alchemilla abyssinica, methanolic extract of the CHCl3/ EtoAc resi...

2005
Tadeusz Librowski

Our previously conducted pharmacological investigations led us to discovery of the strong local anesthetic activity of the compound KP-23RS. The following studies revealed that its Rand S-diasteroisomers had different activity in the local anesthetic, anti-aggregating, anti-arrhythmic and spasmolytic tests. Also the influence of KP-23RS and its diastereoisomers on the cyclic adenosine monophosp...

2011
Damião P. de Sousa Genival A. S. Júnior Luciana N. Andrade Josemar S. Batista

The present study aimed to investigate the correlation between structure and spasmolytic activity of racemate and enantiomers of linalyl and citronellyl acetates, chemical constituents of several bioactive essential oils, such as Thymus leptophyllus essential oil, which contains linalyl acetate as major constituent. The monoterpene esters showed significant spasmolytic activity in guinea-pig is...

2017
Jason C. Mills James R. Goldenring

The development of intestinal-type gastric cancer is preceded by loss of parietal cells (oxyntic atrophy) and the induction of metaplastic cell lineages in the gastric mucosa. For example, mouse models have shown that spasmolytic polypeptide-expressing metaplasia can develop following oxyntic atrophy through transdifferentiation of zymogen-secreting chief cells. Evolution of spasmolytic polypep...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2008
Damião P de Sousa Genival A S Júnior Luciana N Andrade Flávia R Calasans Xirley P Nunes José M Barbosa-Filho Josemar S Batista

Rotundifolone, a monoterpene isolated from the essential oil of the leaves of Mentha x villosa, is a constituent of several essential oils and known to have spasmolytic activity. The present study aimed to investigate the correlation between structure and spasmolytic activity of rotundifolone and its analogues in ileum isolated from guinea-pig. Five of the seven tested analogues were found to h...

Journal: :Pharmacological reports : PR 2005
Tadeusz Librowski

Our previously conducted pharmacological investigations led us to discovery of the strong local anesthetic activity of the compound KP-23RS. The following studies revealed that its R- and S-diasteroisomers had different activity in the local anesthetic, anti-aggregating, anti-arrhythmic and spasmolytic tests. Also the influence of KP-23RS and its diastereoisomers on the cyclic adenosine monopho...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2009
Nury Pérez-Hernández Hector Ponce-Monter Mario I Ortiz Raquel Cariño-Cortés Pedro Joseph-Nathan

Aromadendranes belong to a class of sesquiterpenes present in higher plant essential oils and marine animals. Although the biological activities include antifungal, antibacterial, antiviral, plant growth regulatory, antifeedant, repellent and cytotoxic, there is only one precedent for spasmolytic effects. In a previous report we have shown that the aromadendrene molecule known as spathulenol, i...

Journal: :iranian journal of pharmaceutical research 0
mk gharib naseri h mazlomi m goshaiesh g vakilzadeh heidari a

zataria multiflora boiss. is used in iranian traditional medicine to treat gastrointestinal disorders and menrrhalgia. the inhibitory effect of this herb on rat ileum contractions is also reported. the aim of this study was to investigate the effect of zataria multiflora boiss. hydroalcoholic leaf extract (zhle) on isolated rat uterus in presence of some known uterus stimulants. pieces of virgi...

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