solid lipid nanoparticles (slns) have emerged as an alternative colloidal carriers for sustained release of lipophilic drugs with poor absorption and water solubility. this manuscript describes the effect of process variables on the production of solid lipid nanoparticles (slns) from beeswax and carnauba wax and ketoprofen release from these carriers. it was found that by increasing drug conten...

Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent properties, lipid nanoparticles offer the possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a...

objective(s): in the current study, sunscreen and moisturizing properties of solid lipid nanoparticle (sln)-safranal formulations were evaluated. materials and methods:series of sln were prepared using glyceryl monostearate, tween 80 and different amounts of safranal by high shear homogenization, and ultrasound and high-pressure homogenization (hph) methods. sln formulations were characterized ...

objective(s): the aim of the present study was to prepare, characterize, and evaluate solid lipid nanoparticles (slns) containing zataria multiflora essential oil (zeo). materials and methods: in this study, z. multiflora essential oil-loaded solid lipid nanoparticles (ze-slns) were prepared to improve its efficiency in controlling some fungal pathogens. slns containing z. multiflora essential ...

While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility. Therefore, wogonin-loaded solid lipid nanoparticles were fabricated using a hot-melted evaporation technique. The highest solubility of wogonin was observed in stearic acid. Hence, wogonin-loaded solid lipid nanoparticles were composed of ...

solid lipid nanoparticles of atovaquone (atq-sln) were prepared by high shearhomogenization method using tripalmitin, trilaurin, and compritol 888 ato as the lipidmatrices and phospholipon 90h, tween 80, and poloxamer 188 as the surfactants. optimizationof the formulations was conducted using 6 sets of 24 full-factorial design based on fourindependent variables that were the number of homogeniz...

In this study, the effect of particle size of genistein-loaded solid lipid particulate systems on drug dissolution behavior and oral bioavailability was investigated. Genistein-loaded solid lipid microparticles and nanoparticles were prepared with glyceryl palmitostearate. Except for the particle size, other properties of genistein-loaded solid lipid microparticles and nanoparticles such as par...

topical retinoids are considered as the first line therapy in the treatment of acne vulgaris, but they are associated with cutaneous irritation. in this study, isotretinoin-loaded solid lipid nanoparticles(it-sln) were prepared to treat the mild to moderate acne. also using it-sln would minimize it adverse effects in comparison to commercial product, isotrex®. this study was conducted to prepar...

The present review discusses the potential use of solid lipid nanoparticles for brain drug targeting purposes. The state of the art on surfactant-coated poly(alkylcyanoacrylate) nanoparticles specifically designed for brain targeting is given by emphasizing the transfer of this technology to solid lipid matrices. The available literature on solid lipid nanoparticles and related carriers for bra...

Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, prolong the circulation time of various drugs. SLNs applied in oral, parenteral, transdermal, intranasal, ocular, pulmonary drug delivery different drugs, with enhanced safety, bioavailability, overall th...