BACKGROUND/AIM Neointimal formation after vessel injury is a complex process involving multiple cellular and molecular processes. Inhibition of intimal hyperplasia plays an important role in preventing proliferative vascular diseases, such as restenosis. In this study, we intended to identify whether sodium ferulate could inhibit neointimal formation and further explore potential mechanisms inv...

experimental evidence suggested that sodium ferulate (sf) and oxymatrine (omt) combination had synergistic anti-inflammatory and antioxidant effects. we hypothesized that sf and omt combination treatment might have protective effects on paraquat-induced acute lung injury. in our study, the swiss mice were randomly divided into seven groups, including control, paraquat (pq), sf (6.2 mg/kg/day); ...

Arthritis Research and Th erapy could draw such great interest from the readers. Th e following is our response to Ma and colleagues' concerns [1]. In response to the fi rst question, at the beginning of the research we had screened the entire apoptotic pathways using the Rat Apoptosis RT2 Profi ler™ PCR Array (SABiosciences, Frederick, MD, USA), and the result (Table 1 in the original paper [2...

Reactive oxygen species (ROS) play important roles in the occurrence and development in diabetic cardiomyopathy (DC). Ferulic acid is one of the ubiquitous compounds in diet. Sodium ferulate (SF) is its sodium salt. SF has potent free radical scavenging activity and can effectively scavenge ROS. The study investigated the effect of SF on cardioprotection in diabetic rats. The diabetic rats indu...

The aim of our study was testing whether R. rosea extract and ferulic acid activate expression targets FoxO, regulators energy metabolism autophagy in livers young old mice, to what extent the effects on genes studied coincide. Methods. . C57BL/6J mice were reared at 22 ± 2 °С, 50-60% humidity, 12/12 hour light/dark cycle. All groups a standard chow (4,8% fats, 21,8% protein, 3,9% fibre). Exper...

Jojoba seed meal (Simmondsia chinensis) contains approximately 15% glucosides identified as simmondsin, 5-demethyl simmondsin, didemethyl simmondsin, along with simmondsin 2%-ferulate, 4-demethyl simmondsin 2%-ferulate, and 5-demethyl simmondsin ferulate. The new simmondsin derivative was isolated from jojoba meal by a combination of column chromatography and preparative HPLC and identified by ...