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Background Reproductive dysfunction and endocrine disorders are common among men with complex partial seizures of temporal lobe origin. Diminished sexual desire and responsiveness along with decreased libido and less orgasm are frequently described in men with temporal lobe epilepsy (TLE). It appears that the reduced fertility in epileptic men is accompanied by erectile dysfunction and abnormal...

objective studies on the effect of various antiepileptic drugs on serum lipids show contradictory results. we aimed to find the effect of phenobarbital and sodium valproate monotherapy on serum lipid profile and liver function tests in epileptic children. materials & methods this cohort study was conducted in amirkola children hospital. one hundred and ten children with epilepsy were included i...

migraine is a common and incapacitating neurologic disorder manifesting with episodic moderate to a severe headache and other symptoms such as photophobia, phonophobia, nausea, and vomiting. triptans and ergot compounds have been used as treatment options for an acute migraine headache for many years. triptans are considered the first line of treatment in patients with moderate to a severe migr...

    In this double blind crossover study we assessed the bioequivalence of 200 mg enteric coated sodium valproate tablets manufactured by Roozdarou with 200 mg enteric coated sodium valproate (Orlept) manufactured by Desitin, Germany. Twelve healthy male volunteers were administered a single dose of 600 mg sodium valproate manufactured by Roozdarou, followed by a similar dose of Orlept, 2 weeks...

Sodium valproate has been widely used by man as an antiepileptic drug. Hair loss and curly hair is a rare side effect of sodium valproate. We have conducted a prospective clinical study in the Department of Neurology in Shafa Hospital, Kerman, Iran for ten years (1994-2004). All 211 epileptic patients in our study were given sodium valproate as a single drug treatment. During the course of ther...

Background: The interaction between antiepileptic drugs and brain electrical stimulation is a potential therapy to control of seizures in patient with pharmacoresistance to drugs. So, the aim of present study was designed to determine the effect of a sub effective dose of sodium valproate combined with low-frequency electrical stimulation during kindling. Material and Methods: One tripolar ele...

objective: to investigate possible immunological humoral correlates in newly diagnosed adult-onset generalized tonic-clonic epilepsy among iranian patients before and after sodium valproate treatment.   patients and methods: 72 adult patients with newly diagnosed idiopathic generalized tonic-clonic epilepsy were recruited. serum antinuclear antibodies (ana), anti-cardiolipin antibodies (acl), a...