1 The effects of 4-Chloro-m-Cresol (4-CmC) were examined on heterologously expressed wild type (WT), Paramyotonia Congenita (R1448H) and Hyperkalemic Periodic Paralysis (M1360V) mutant alpha-subunits of human muscle sodium channels. 2 Block of rested sodium channels caused by 4-CmC was concentration-dependent with an ECR50 of 0.40 mM in WT, 0.45 mM in R1448H and 0.49 mM in M1360V. 3 Inactivatio...

Ketoprofen is a potent non-steroidal anti-inflammatory drug which is used for the treatment of rheumatoid arthritis. The oral administration of ketoprofen can cause gastric irritation and renal adverse effects. Topical application of the drug can bypass gastrointestinal disturbances and provide relatively consistent drug levels at the site of action. Since the efficacy of gels depends on the ty...

In this study we investigated resveratrol (trans-3,5,4'-trihydroxystilbene) solubilization with sodium 3α,12 α-dihydroxy-7-oxo-5 β-cholanoate (S7-OD) and sodium dodecyl sulfate (SDS). The investigation was aimed at determining whether large spherical micelles (SDS) or small longitudinal micelles (S7-OD) are more convenient for incorporation of resveratrol. Also, we studied resveratrol behavior ...

Water-soluble fluorescent probes, including 1-pyrene butyric acid, rhodamine B, sodium salt 1,5diaminoanthraquinone-2,6-disulfonic acid, quinine hemisulfate and monosodium salt 8-amino1-naphthol-3,6-disulfonic acid were used to determine the critical micelle concentration (cmc) of inverted micelles formed by cholic acid in tetrahydrofuran. Another water-insoluble fluorescent probe, namely pyren...

Carboxymethyl cellulose [C6H7O(OH)3x(OCH2COOH)x]n is a derivative of the regenerated cellulose [C6H10O5]n with hydroxy-acetic acid (hydroxy ethanoic acid) CH2(OH)COOH or sodium monochloroacetate ClCH2COONa. The CMC backbone consist of D-glucose residues linked by -1,4-linkage. The molecular mass of one glucose unit in CMC chain is mCMC = 146.14 + 75.04x, where x  3 is the degree of substitu...

Variations in the critical micelle concentration (CMC) have been determined for sodium dodecyl sulfate and sodium deoxycholate (NaDC) in the presence of five drugs and polyethylene glycol (PEG) at 298.2, 304.2 and 310.2 K. From these data, thermodynamic parameters associated with the micellisation process (∆Gmic, ∆Hmic and ∆Smic) were calculated. In the presence of some drug-based compounds the...

Mucoadhesive buccal patch of Aceclofenac were prepared using polymer like Gelatin, Poly Sodium CMC and Poly Vinyl Alcohol. Eight formulations were prepared with varying the concentration of Poly Sodium CMC and evaluated for various parameters like weight variation, patch thickness, volume entrapment efficiency %, and measurement of % elongation at break, folding endurance, in vitro mucoadhesive...

Molecular dynamics simulations of diluted (≈ 2.5 weight percent) aqueous solutions of two polyelectrolytes, namely sodium carboxy methyl cellulose (CMC) and sodium poly(acrylate) (PAA) have been performed. Water and counterions were taken into account explicitly. For CMC the substitution pattern and starting conformation is all-important. Two simulations of CMC oligomers resulted in different s...

The purpose of this study was to investigate the influence of different hydrophilic polymers on the swelling, bioadhesion and mechanical strength of hydrocolloid wound dressings (HCDs) in order to provide an appropriate composition for a hydrocolloid wound dressing system. In this study, the HCDs were prepared with styrene-isoprene-styrene copolymer (SIS) and polyisobutylene (PIB) as the base u...

Androst-3β,5α,6β-triol (Triol) is a promising neuroprotective agent, but its poor solubility restricts its development into parenteral preparations. In this study, Triol is significantly solubilized by bile salt/phosphatidylcholine mixed micelles (BS/PC-MM). All BS/PC-MM systems are tested to remarkably improve the drug solubility with various stabilities after drug loading. Among them, the sod...