نتایج جستجو برای: Sodium/iodide symporter

تعداد نتایج: 2459  

Journal: :Blood 2003
David Dingli Rosa Maria Diaz Elizabeth R Bergert Michael K O'Connor John C Morris Stephen J Russell

Multiple myeloma is a disseminated neoplasm of terminally differentiated plasma cells that is incurable with currently available therapies. Although the disease is radiosensitive, external beam radiation leads to significant toxicity due to sensitive end-organ damage. Thus, genetic approaches for therapy are required. We hypothesized that the incorporation of immunoglobulin promoter and enhance...

Journal: :Endocrinology 2001
T Kogai J M Hershman K Motomura T Endo T Onaya G A Brent

The absence of TSH-stimulated radioiodide uptake in differentiated thyroid cancer is associated with a high recurrence rate and reduced survival. We studied regulation of the sodium/iodide symporter gene in human papillary thyroid cancer cell lines (BHP) and primary human thyroid cells. BHP cells expressed very low levels of sodium/iodide symporter mRNA and did not concentrate iodide, but iodid...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
T J Chiou D R Bush

The proton-sucrose symporter mediates the key transport step in the resource distribution system that allows many plants to function as multicellular organisms. In the results reported here, we identify sucrose as a signaling molecule in a previously undescribed signal-transduction pathway that regulates the symporter. Sucrose symporter activity declined in plasma membrane vesicles isolated fro...

Journal: :International journal of clinical and experimental medicine 2015
Jun-Yu Zhao Huan-Jun Wang Hai-Peng Wang Jin-Ming Yao Xiao-Yun Wu Hong-Xia Shang Rui Zhang Huan-Gao Zhu Jian-Jun Dong Lin Liao

BACKGROUND Methylation of sodium iodide symporter promoter has been reported to increase the incidence of papillary thyroid carcinoma (PTC). In this meta-analysis stratified via methylation of sodium iodide symporter promoter, we evaluate the relationship between methylation of sodium iodide symporter promoter and PTC. The association between methylation with aggressiveness and metastasis poten...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Matthew W Vaughn Gregory N Harrington Daniel R Bush

A proton-sucrose symporter mediates the key step in carbon export from leaves of most plants. Sucrose transport activity and steady-state mRNA levels of BvSUT1, a sugar beet leaf sucrose symporter, are negatively regulated specifically by sucrose. Results reported here show that BvSUT1 mRNA was localized to companion cells of the leaf's vascular system, which supports its role in the systemic d...

Journal: :The Journal of experimental biology 1995
A L Bader R Parthasarathy W R Harvey

Alkali-cation-dependent uptake of proline and glycine into brush-border membrane vesicles from the midgut of the larval tobacco hornworm Manduca sexta was investigated using rapid filtration assays. Uptake of both amino acids was by electrophoretic symport, with K+ being the favored cation at pH 10. Counterflow accumulation of proline was elicited by glycine and vice versa, suggesting that the ...

2014
Iliana Pereira Ana Madeira Catarina Prista Maria C. Loureiro-Dias Maria José Leandro

Debaryomyces hansenii is a halotolerant yeast that produces and assimilates a wide variety of polyols. In this work we evaluate polyol transport in D. hansenii CBS 767, detecting the occurrence of polyol/H(+) (and sugar/H(+)) symporter activity, through the transient extracellular alkalinization of unbuffered starved cell suspensions. From the D. hansenii genome database, we selected nine ORFs ...

2013
Maria José Leandro Hana Sychrová Catarina Prista Maria C. Loureiro-Dias

Zygosaccharomyces rouxii is a fructophilic yeast than can grow at very high sugar concentrations. We have identified an ORF encoding a putative fructose/H(+) symporter in the Z. rouxii CBS 732 genome database. Heterologous expression of this ORF in a S. cerevisiae strain lacking its own hexose transporters (hxt-null) and subsequent kinetic characterization of its sugar transport activity showed...

2017
Karina Quiaoit

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