نتایج جستجو برای: Snail2

تعداد نتایج: 124  

Journal: :Cancer research 2011
Esmeralda Casas Jihoon Kim Andrés Bendesky Lucila Ohno-Machado Cecily J Wolfe Jing Yang

To metastasize, carcinoma cells must attenuate cell-cell adhesion to disseminate into distant organs. A group of transcription factors, including Twist1, Snail1, Snail2, ZEB1, and ZEB2, have been shown to induce epithelial mesenchymal transition (EMT), thus promoting tumor dissemination. However, it is unknown whether these transcription factors function independently or coordinately to activat...

2012
Patricia Molina-Ortiz Ana Villarejo Matthew MacPherson Vanesa Santos Amalia Montes Serhiy Souchelnytskyi Francisco Portillo Amparo Cano

Snail1 and Snail2, two highly related members of the Snail superfamily, are direct transcriptional repressors of E-cadherin and EMT inducers. Previous comparative gene profiling analyses have revealed important differences in the gene expression pattern regulated by Snail1 and Snail2, indicating functional differences between both factors. The molecular mechanism of Snail1-mediated repression h...

Journal: :Development 2006
Daisuke Sakai Takashi Suzuki Noriko Osumi Yoshio Wakamatsu

In neural crest formation, transcription factors, such as group E Sox and Snail1/Snail2 (Slug) regulate subsequent epithelial-mesenchymal transition (EMT) and migration. In particular, Sox9 has a strong effect on neural crest formation, EMT and differentiation of crest-derived cartilages in the cranium. It remains unclear, however, how Sox9 functions in these events, and how Sox9 activity is re...

Journal: :The EMBO journal 2011
Kangae Lee Nikolce Gjorevski Eline Boghaert Derek C Radisky Celeste M Nelson

Several E-box-binding transcription factors regulate individual and collective cell migration and enhance the motility of epithelial cells by promoting epithelial-mesenchymal transition (EMT). Here, we characterized the role of a subset of these transcription factors and the EMT proteome in branching morphogenesis of mammary epithelial tissues using a three-dimensional organotypic culture model...

Journal: :Development 2011
Jianli Shi Courtney Severson Jianxia Yang Doris Wedlich Michael W Klymkowsky

The neural crest is an induced tissue that is unique to vertebrates. In the clawed frog Xenopus laevis, neural crest induction depends on signals secreted from the prospective dorsolateral mesodermal zone during gastrulation. The transcription factors Snail2 (Slug), Snail1 and Twist1 are expressed in this region. It is known that Snail2 and Twist1 are required for both mesoderm formation and ne...

Journal: :Development 2007
Lisa A Taneyhill Edward G Coles Marianne Bronner-Fraser

The neural crest, a transient population of migratory cells, forms the craniofacial skeleton and peripheral nervous system, among other derivatives in vertebrate embryos. The transcriptional repressor Snail2 is thought to be crucial for the epithelial-to-mesenchymal transition (EMT) that promotes neural crest delamination from the neural tube; however, little is known about its downstream targe...

2012
Pablo H. Strobl-Mazzulla Marianne E. Bronner

Neural crest cells form within the neural tube and then undergo an epithelial to mesenchymal transition (EMT) to initiate migration to distant locations. The transcriptional repressor Snail2 has been implicated in neural crest EMT via an as of yet unknown mechanism. We report that the adaptor protein PHD12 is highly expressed before neural crest EMT. At cranial levels, loss of PHD12 phenocopies...

2015
Chih-Liang Tien Amanda Jones Hengbin Wang Magda Gerigk Susan Nozell

Neural crest cells arise from the border of the neural plate and epidermal ectoderm,migrate extensively and differentiate into diverse cell types during vertebrate embryogenesis. Althoughmuch has been learnt about growth factor signals and gene regulatory networks that regulate neural crest development, limited information is available on how epigenetic mechanisms control this process. In this ...

مقدمه:CD105 یک گلیکوپروتئین غشایی همودیمریک است که در رگ‏سازی جدید نقش دارد. Snail2 یک فاکتور رونویسی بوده و منجر به اختلال در چسبندگی اپی‏تلیالی می‏گردد. هدف مطالعه حاضر ارزیابی بیان CD105 و Snail2 در اپی‏تلیوم دیسپلاستیک و کارسینوم سلول سنگفرشی دهان بود. مواد و روش‏ها: در این مطالعه توصیفی-تحلیلی، جمعاً 40 بلوک پارافینه کارسینوم سلول سنگفرشی و اپی‏تلیوم دیسپلاستیک با نشانگر CD105 و Snail2 به...

2013
Amir-Shaya Sharili Steve Allen Ken Smith Joanna Price Imelda M. McGonnell

The function of Snail2 in mesenchymal tumors is, to date unknown. Using knockdown and overexpression studies, we show that Snail2 regulates migration and invasion of osteosarcoma cells. Knockdown resulted in significantly decreased motility, remodelling of the actin cytoskeleton, and loss of cellular protrusions. Over-expression increased motility, formation of actin-rich cellular protrusions, ...

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