نتایج جستجو برای: Single nucleotide polymorphism

تعداد نتایج: 1014701  

Journal: :iranian biomedical journal 0
mohsen naseri mehdi hedayati maryam sadat daneshpour fatemeh bandarian fereidoun azizi

background: the serum concentration of high-density lipoprotein cholesterol (hdl-c) is one of the important heritable risk factors for cardiovascular disease and is a target for therapeutic intervention. in this study, we aimed to evaluate the effects of lecithin cholesterol acyltransferase (lcat) gene polymorphism rs5923 on lcat enzyme activity and serum hdl-c concentration. methods: the study...

متن کامل
Journal: :iranian journal of public health 0
sf tee py tang hc loh

background: molecular components of the dopamine receptor (drd3) play an important role in the pathophysiology of schizophrenia (scz). previous studies have demonstrated an association between the drd3 ser9gly polymorphism and scz but the results have been inconclusive. method: in this study, we investigated this controversial association between the ser9gly (a/g) polymorphism and scz using mal...

متن کامل
Journal: :iranian red crescent medical journal 0
ali mohammad foroughmand faculty of science, department of genetics, shahid chamran university of ahvaz, ahvaz, ir iran zahra shahbazi faculty of science, department of genetics, shahid chamran university of ahvaz, ahvaz, ir iran; faculty of science, department of genetics, shahid chamran university of ahvaz, ahvaz, ir iran. tel: +98-9380889172 hamid galehdari faculty of science, department of genetics, shahid chamran university of ahvaz, ahvaz, ir iran mahdi purmahdi borujeni faculty of veterinary medicine, department of food hygiene, shahid chamran university of ahvaz, ahvaz, ir iran parvane dinarvand faculty of science, department of genetics, shahid chamran university of ahvaz, ahvaz, ir iran khadije golabgirkhademi faculty of science, department of genetics, shahid chamran university of ahvaz, ahvaz, ir iran

background coronary artery disease (cad) is the most common cause of death worldwide. mef2a directly regulates target genes in the process of muscle development. this gene product is a transcription factor. mef2a protein in homodimer or heterodimer forms binds to a/t-rich cis elements with conserved sequence in promoter, regulator, and enhancer of many genes, which are determining in evolution ...

متن کامل
Journal: :iranian journal of public health 0
n parvaneh dept. of pediatrics, infectious disease research center, children's medical center, tehran universit b pourakbari dept. of pediatrics, infectious disease research center, children's medical center, tehran universit kh daneshjoo dept. of pediatrics, imam khomeini hospital, tehran university of medical sciences, iran h ashraf dept. of pediatrics, infectious disease research center, children's medical center, tehran universit a salavati dept. of pediatrics, infectious disease research center, children's medical center, tehran universit s mamishi dept. of pediatrics, infectious disease research center, children’s medical center, tehran universit

background: cytokines and specially interferon-gamma (ifn-g) are largely responsible for the regulation of the protective im­mune response against mycobacterial infections. several studies have clarified the importance of common variants of ifn- g gene regarding the susceptibility to tuberculosis. bacille calmette-guérin (bcg) vaccine that is used to prevent se­vere forms of tuberculosis could ...

متن کامل
Journal: :hepatitis monthly 0
imran tipu institute of biochemistry and biotechnology, university of the punjab, lahore, pakistan; manchester institute of biotechnology, university of manchester, manchester, uk; institute of biochemistry and biotechnology, university of the punjab, lahore, pakistan. tel: +92-3214029804 fiona marriage manchester institute of biotechnology, university of manchester, manchester, uk; centre for integrated genomic medical research, university of manchester, manchester, uk zia-ur-rahman farooqi manchester institute of biotechnology, university of manchester, manchester, uk; national university of science and technology, islamabad, pakistan hazel platt centre for integrated genomic medical research, university of manchester, manchester, uk muhammad amin athar institute of biochemistry and biotechnology, university of the punjab, lahore, pakistan philip john day manchester institute of biotechnology, university of manchester, manchester, uk; centre for integrated genomic medical research, university of manchester, manchester, uk

background polymorphisms in the interferon λ (inf λ) genes on chromosome 19 have been associated with clearance of hepatitis c virus (hcv) induced by interferon and ribavirin therapy however there is no such data available for pakistani patients with hcv infection. objectives in this study, the effects of single nucleotide polymorphisms (snps) have been investigated in response to treatment wit...

متن کامل
Journal: :iranian journal of allergy, asthma and immunology 0
ali mosayebian department of immunology, school of medicine, isfahan university of medical sciences, isfahan, iran. mazdak ganjalikhani-hakemi cellular and molecular immunology research center, faculty of medicine, isfahan university of medical sciences, isfahan, iran. rezvan meshkat department of immunology, faculty of medicine, shahrekord university of medical sciences, shahrekord, iran. ramin ghasemi department of immunology, school of medicine, isfahan university of medical sciences, isfahan, iran. hossain khan-ahmad department of genetics and molecular biology, faculty of medicine, isfahan university of medical sciences, isfahan, iran. morteza samadi department of immunology, faculty of medicine, shahid sadoughi university of medical sciences, yazd, iran and reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, iran.

the snp (rs11209026, arg381gln, r381q) in the il-23 receptor (il23r) confers protection against multiple inflammatory diseases, representing one of the most significant human genetic polymorphisms in inflammatory diseases. we, therefore, investigated the association between il-23 r r381q gene polymorphism and asthma.this case-control study was performed on 209 patients, and 200 healthy controls...

متن کامل
ژورنال: :iranian red crescent medical journal 0
zahra mojtahedi shiraz institute for cancer research, shiraz university of medical sciences, ir iran nasroolah erfani shiraz institute for cancer research, shiraz university of medical sciences, ir iran mahyar malekzadeh shiraz institute for cancer research, shiraz university of medical sciences, ir iran mohammad reza haghshenas shiraz institute for cancer research, shiraz university of medical sciences, ir iran abbas ghaderi shiraz institute for cancer research, shiraz university of medical sciences, ir iran alamtaj samsami dehaghani department of obstetrics and gynecology, shiraz university of medical sciences, ir iran +98-7112303687, samsamia@sums.ac.ir; department of obstetrics and gynecology, shiraz university of medical sciences, ir iran +98-7112303687, samsamia@sums.ac.ir

background the association between her2 ile655val single nucleotide polymorphism and cancer is controversial. objectives the aim of our study was to investigate this polymorphism in patients with ovarian cancer. patients and methods genomic dna was extracted from peripheral blood leukocytes of 107 patients and 130 healthy women. her2 gene polymorphism was assessed by pcr-rflp. results no signif...

متن کامل
Journal: :hepatitis monthly 0
jie fan department of epidemiology, school of public health and management, research center for medicine and social development, innovation center for social risk governance in health, chongqing medical university, chongqing, china xin huang department of epidemiology, school of public health and management, research center for medicine and social development, innovation center for social risk governance in health, chongqing medical university, chongqing, china juan chen key laboratory of molecular biology for infectious diseases, institute for viral hepatitis, department of infectious diseases, the second affiliated hospital, chongqing medical university, chongqing, china yiling cai obstetrics and gynecology department, chengdu women and children’s central hospital, sichuan province, china lin xiong maternal and child health hospital of chongqing yuzhong district, chongqing, china lihong mu department of epidemiology, school of public health and management, research center for medicine and social development, innovation center for social risk governance in health, chongqing medical university, chongqing, china; research center for medicine and social development, innovation center for social risk governance in health, school of public health and management, chongqing medical university, chongqing, china. tel/fax: +86-2368485008

background hepatitis b virus (hbv) infection is a serious public health problem in china and worldwide. mother-to-child transmission is one of hbv’s main transmission routes in highly endemic regions. genome-wide association studies (gwas) identify single nucleotide polymorphisms (snps) at hla loci as associated with hbv infection. however, the mechanisms of hbv perinatal transmission and break...

متن کامل
Journal: :iranian journal of basic medical sciences 0
tausif ahmed rajput department of biochemistry and molecular biology, centre for research in experimental and applied medicine (cream), army medical college, national university of sciences & technology (nust), islamabad, pakistan abdul khaliq naveed department of biochemistry and molecular biology, centre for research in experimental and applied medicine (cream), army medical college, national university of sciences & technology (nust), islamabad, pakistan shakir khan department of biochemistry and molecular biology, centre for research in experimental and applied medicine (cream), army medical college, national university of sciences & technology (nust), islamabad, pakistan zia-ur rehman farooqi department of biochemistry and molecular biology, centre for research in experimental and applied medicine (cream), army medical college, national university of sciences & technology (nust), islamabad, pakistan

objective(s):organic anion transporter polypeptide 1b1 (oatp1b1) encoded by solute carrier organic transporter 1b1 (slco1b1) gene; a transporter involved in the uptake of drugs and endogenous compounds is present in hepatocyte sinusoidal membrane. aim of this study was to investigate the frequencies of functionally significant snps (388a>g and 521t>c) and their haplotypes in 6 ethnic groups of ...

متن کامل
ژورنال: :thrita 0
bahareh moradi najafabad branch, islamic azad university, najafabad, isfahan, iran hossein tabatabaeian genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran samira sadeghi genetics division, biology department, faculty of sciences, university of isfahan, isfahan, iran mansoureh azadeh najafabad branch, islamic azad university, najafabad, isfahan, iran kamran ghaedi cellular and molecular biology division, biology department, faculty of sciences, university of isfahan, isfahan, iran; cellular and molecular biology division, biology department, faculty of sciences, university of isfahan, isfahan, iran. tel: +98-3137932479, fax: +98-3137932456

conclusions rs1595065 could be recommended as a risk factor in regulating her4 expression and affecting her2 positivity incidence among bc patients. methods overall, 156 patients and controls were genotyped using rflp-pcr. armitage test for trend was utilized to investigate the association between rs1595065 and susceptibility to bc. the possible change in the interaction between rs1595065 and m...

متن کامل

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید

function paginate(evt) { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term pg=parseInt(evt.target.text) var data={ "year":filter_year, "term":term, "pgn":pg } filtered_res=post_and_fetch(data,url) window.scrollTo(0,0); } function update_search_meta(search_meta) { meta_place=document.getElementById("search_meta_data") term=search_meta.term active_pgn=search_meta.pgn num_res=search_meta.num_res num_pages=search_meta.num_pages year=search_meta.year meta_place.dataset.term=term meta_place.dataset.page=active_pgn meta_place.dataset.num_res=num_res meta_place.dataset.num_pages=num_pages meta_place.dataset.year=year document.getElementById("num_result_place").innerHTML=num_res if (year !== "unfilter"){ document.getElementById("year_filter_label").style="display:inline;" document.getElementById("year_filter_place").innerHTML=year }else { document.getElementById("year_filter_label").style="display:none;" document.getElementById("year_filter_place").innerHTML="" } } function update_pagination() { search_meta_place=document.getElementById('search_meta_data') num_pages=search_meta_place.dataset.num_pages; active_pgn=parseInt(search_meta_place.dataset.page); document.getElementById("pgn-ul").innerHTML=""; pgn_html=""; for (i = 1; i <= num_pages; i++){ if (i===active_pgn){ actv="active" }else {actv=""} pgn_li="
  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->