A simple and accurate method of analysis to determine Sitagliptin Phosphate (STG) and Simvastatin(SMV) in combined dosage forms was developed using simultaneous equation method at 267.0nm for Simvastatin and 238.0 nm for Simvastatin in spectra of their solutions in methanol: water(90:10). The calibration curves were linear [correlation coefficient (r) = 0.986 for STG and 0.998 for SMV] in conce...

Dendrimers have a highly branched nanoscale architecture with low polydispersity and high functionality. Therefore, dendrimers been widely used for nanocarriers in drug delivery systems. This paper gives an overview of the recent progress on the evaluation of pharmacokinetic and pharmacodynamic (PK/PD) profiles of PAMAM dendrimers based Simvastatin (SMV) oral formulation in rats. The mechanism ...

abstract: background: statins are the recently evolved agents that aid in periodontal regeneration and ultimately attaining periodontal health. atorvastatin (atv) and simvastatin (smv) are specific competitive inhibitors of 3-hydroxy-2-methyl-glutaryl coenzyme a reductase. the present study was designed to evaluate and compare the effectiveness of 1.2% atv, and 1.2% smv as an adjunct to scaling...

The present study was undertaken to evaluate the possible protective effects of simvastatin (SMV) against oxidative stress in streptozotocin- (STZ)-induced diabetic rats. Diabetes was induced experimentally in rats by i.p. injection of STZ in a dose of 60 mg/kg bwt. After 5 weeks of STZ injection, there were apparent reductions in the animal body weight and significant increase in blood glucose...

Time and cost saving is an essential requirement in pharmacokinetics and bioequivalence studies. The aim of this study is to use a simple, fast, and nondestructive near-infrared transmission spectroscopic method to quantify simvastatin (SMV) concentrations in mice plasma and also to improve SMV bioavailability by using alpha-lipoic acid as a carrier. Calibration curve was built at a concentrati...

The current study focuses on utilization of the natural biocompatible polymer zein to formulate simvastatin (SMV) nanoparticles coated with caseinate, to improve solubility and hence bioavailability, and in addition, to modify SMV-release characteristics. This formulation can be utilized for oral or possible depot parenteral applications. Fifteen formulations were prepared by liquid-liquid phas...

Background. Statins are the recently evolved agents that aid in periodontal regeneration and ultimately in attaining periodontal health. Atorvastatin (ATV) and Simvastatin (SMV) are specific competitive inhibitors of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. The current study was conducted to compare the effectiveness of 1.2% ATV and 1.2% SMV, in addition to scaling and root planing (SR...

This study investigates the effects of simvastatin (SMV) on human umbilical vein endothelial cells (HUVECs) inflamed by tumor necrosis factor-alpha (TNF-a). Cells were treated with (5 μM, 10 and 50 μM) with/without TNF (20 ng/mL). The proliferation examined, its cytotoxic effect was determined lactate dehydrogenase (LDH) assays. Metalloproteinase expression (MMP-2 MMP-9) levels SMV at different...

The role of oxidative stress has been reported in various diabetic complications. The present study was undertaken to evaluate the possible protective effects of simvastatin (SMV), a HMG-CoA reductase inhibitor against oxidative stress in streptozotocin (STZ) induced diabetic rats. Diabetes induced in rats by a single intraperitoneal injection of STZ (6o mg/Kg). A dose of 10 mg/kg of either SMV...

Sensitive, simple, reliable and rapid HPLC technique for the estimation of simvastatin (SMV) and cetirizine has been designed in this study. The chromatographic conditions were set using Shimadzu LC-10 AT VP pump, with UV detector (SPD-10 AV-VP). System integration was performed with CBM-102 (Bus Module). Partitioning of components was attained with pre-packed C-18 column of Purospher Star (5 μ...