نتایج جستجو برای: Shogaol

تعداد نتایج: 216  

2012
Rong Hu Ping Zhou Yong-Bo Peng Xiaojun Xu Jiang Ma Qun Liu Lei Zhang Xiao-Dong Wen Lian-Wen Qi Ning Gao Ping Li

6-Shogaol is an active compound isolated from Ginger (Zingiber officinale Rosc). In this work, we demonstrated that 6-shogaol induces apoptosis in human hepatocellular carcinoma cells in relation to caspase activation and endoplasmic reticulum (ER) stress signaling. Proteomic analysis revealed that ER stress was accompanied by 6-shogaol-induced apoptosis in hepatocellular carcinoma cells. 6-sho...

2017
Qinghe Han Qinghai Yuan Xiaolin Meng Junyuan Huo Yuxin Bao Guanghong Xie

6-Shogaol, a pungent agent isolated from Zingiber officinale Roscoe, has been known to have anti-tumor and anti-inflammatory effects. However, the anti-inflammatory effects and biological mechanism of 6-Shogaol in LPS-activated BV2 microglia remains largely unknown. In this study, we evaluated the anti-inflammatory effects of 6-Shogaol in LPS-activated BV2 microglia. 6-Shogaol was administrated...

2013
Yun kai Wang Ya Jun Hong Yong hua Yao Xiao Min Huang Xue Bo Liu Chun Yu Zhang Lei Zhang Xiaoliang Leon Xu

Endothelial dysfunction and oxLDL are believed to be early and critical events in atherogenesis. 6-Shogaol is the major bioactive compound present in Zingiber officinale and possesses the anti-atherosclerotic effect. However, the mechanisms remain poorly understood. The goal of this study was to investigate the effects of 6-shogaol on oxLDL-induced Human umbilical vein endothelial cells (HUVECs...

Journal: :Molecules 2017
Chi-Ming Liu Chiu-Li Kao Yu-Ting Tseng Yi-Ching Lo Chung-Yi Chen

Ginger has many bioactive compounds with pharmacological activities. However, few studies are known about these bioactive compounds activity in chemoresistant cells. The aim of the present study was to investigate the anticancer properties of ginger phytochemicals in docetaxel-resistant human prostate cancer cells in vitro. In this study, we isolated 6-gingerol, 10-gingerol, 4-shogaol, 6-shogao...

Journal: :Phytomedicine : international journal of phytotherapy and phytopharmacology 2015
S R Feroz S B Mohamad G S Lee S N A Malek S Tayyab

BACKGROUND 6-Shogaol, one of the main bioactive constituents of Zingiber officinale has been shown to possess various therapeutic properties. Interaction of a therapeutic compound with plasma proteins greatly affects its pharmacokinetic and pharmacodynamic properties. PURPOSE The present investigation was undertaken to characterize the interaction between 6-shogaol and the main in vivo transp...

2015
Anasuya Ray Smreti Vasudevan Suparna Sengupta Masaru Katoh

Cancer stem cells (CSCs) pose a serious obstacle to cancer therapy as they can be responsible for poor prognosis and tumour relapse. In this study, we have investigated inhibitory activity of the ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture. The spheroids were generated from adherent breast cancer cells. 6-shogaol ...

2014
Huey-Chun Huang Shu-Jen Chang Chia-Yin Wu Hui-Ju Ke Tsong-Min Chang

[6]-Shogaol is the main biologically active component of ginger. Previous reports showed that [6]-shogaol has several pharmacological characteristics, such as antioxidative, anti-inflammatory, antimicrobial, and anticarcinogenic properties. However, the effects of [6]-shogaol on melanogenesis remain to be elucidated. The study aimed to evaluate the potential skin whitening mechanisms of [6]-sho...

2017
Syntyche Ling Sing Seow Sok Lai Hong Guan Serm Lee Sri Nurestri Abd Malek Vikineswary Sabaratnam

BACKGROUND Ginger is a popular spice and food preservative. The rhizomes of the common ginger have been used as traditional medicine to treat various ailments. 6-Shogaol, a pungent compound isolated from the rhizomes of jahe gajah (Zingiber officinale var officinale) has shown numerous pharmacological activities, including neuroprotective and anti-neuroinflammatory activities. The aim of this s...

Journal: :The West Indian medical journal 2009
A S A Levy O R Simon

OBJECTIVE We previously reported that 6-shogaol, a phenolic compound from ginger has antiinflammatory properties in a Complete Freund's Adjuvant (CFA) model of mono-arthritic rats. In the present study, we investigated the effects of 6-shogaol on the production of inflammatory mediators from lipopolysaccharide (LPS) activated RAW 264.7 macrophages. These mediators (TNF-alpha, IL-1-beta and NO) ...

2012
Qun Liu Yong-Bo Peng Lian-Wen Qi Xiao-Lan Cheng Xiao-Jun Xu Le-Le Liu E-Hu Liu Ping Li

Cervical cancer is one of the most common cancers among women in the world. 6-Shogaol is a natural compound isolated from the rhizome of ginger (Zingiber officinale). In this paper, we demonstrated that 6-shogaol induced apoptosis and G2/M phase arrest in human cervical cancer HeLa cells. Endoplasmic reticulum stress and mitochondrial pathway were involved in 6-shogaol-mediated apoptosis. Prote...

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