FcgammaR-mediated phagocytosis of IgG-coated particles is a complex process involving the activation of multiple signaling enzymes and is regulated by the inositol phosphatases PTEN (phosphatase and tensin homolog deleted on chromosome 10) and SHIP-1 (Src homology [SH2] domain-containing inositol phosphatase). In a recent study we have demonstrated that SHIP-2, an inositol phosphatase with high...

This survey discusses recent developments in the context of spherical designs and minimal energy point configurations on spheres. The recent solution of the long standing problem of the existence of spherical t-designs on S with O(td) number of points by A. Bondarenko, D. Radchenko, and M. Viazovska attracted new interest to this subject. Secondly, D. P. Hardin and E. B. Saff proved that point ...

This quarter we modified the database to account for the ship classification and ship counting guidance in the Secretary of the Navy’s Instruction 5030.8A [3]. First, we inserted four new fields: 1. 5030.8A Force Category – “Battleforce” or “Non-Battleforce.”1, 2 2. 5030.8A Ship Category – “Combatant Ship,” “Auxiliary Ship,” or “Combatant Craft.” 3. 5030.8A Ship Classification – For example: “W...

To reduce water traffic accident, identification of overloaded ships has been of major importance for enforcing inland river management, especially in some developing countries. Driven by rising oil prices or other economic benefits, the ship overload phenomenon continued to occur in China. Therefore, overloaded ship detection has been of a key factor of shipping safety. This paper presented a ...

Our recent studies revealed that the inositol phosphatase Src homology 2 (SH2) domain-containing inositol phosphatase (SHIP) is phosphorylated and associated with Shc exclusively under negative signaling conditions in B cells, which is due to recruitment of the SHIP SH2 domain to the FcgammaRIIb. In addition, we reported that SHIP-Shc interaction involves both SHIP SH2 and Shc phosphotyrosine b...

The SH2-containing inositol-5'-phosphatase, SHIP, restrains bone marrow-derived mast cell (BMMC) degranulation, at least in part, by hydrolyzing phosphatidylinositol (PI)-3-kinase generated PI-3,4,5-P(3) (PIP3) to PI-3,4-P(2). To determine which domains within SHIP influence its ability to hydrolyze PIP3, bone marrow from SHIP(-/-) mice was retrovirally infected with various SHIP constructs. In...

determining the responses of floating structures at sea are the most important concerns in shipbuilding industry. in physical and dynamical principles a ship can be analyzed as a free elastic beam floating in sea without any supports. the analysis of corresponding dynamic equations are difficult and time- consuming, thus investigation on the behavior of floating structures can be done numerical...

LPS stimulates monocytes/macrophages through TLR4, resulting in the activation of a series of signaling events that potentiate the production of inflammatory mediators. Recent reports indicated that the inflammatory response to LPS is diminished by PI3K, through the activation of the serine/threonine kinase Akt. SHIP is an inositol phosphatase that can reverse the activation events initiated by...