Shingles is caused by the human herpesvirus-3 (HHV-3). Primary infection usually occurs in childhood, producing chickenpox (varicella) although it can be subclinical. After this the virus lies dormant in the sensory nervous system in the geniculate, trigeminal or dorsal root ganglia. It may lie dormant for many years or many decades, kept in check by the immune system before flaring up in a sin...

Blood lymphocyte distributions, serum immunoglobulin and cytokine levels, and serum IgE and IgG anti-varicella zoster virus (VZV) levels were measured in an atopic girl (age 15 yr) who developed shingles 10 yr after infection with chicken pox. Before, during, and 5 months after the shingles episode, the child's distributions of blood lymphocytes (excluding CD23+) and serum immunoglobulin levels...

Nearly 1 million new cases of shingles occur each year in the United States. The current life time risk for shingles is 25% and believed to be related to age-related decline in cell-mediated immunity. Risk for shingles is expected to rise as the baby boomer generation age and numbers of chronically immunocompromised persons related to chemotherapy or organ transplantation increase. Shingles has...

BACKGROUND Primary Sjögren's syndrome (pSS) is associated with immunological dysfunctions--a well-known risk factor of shingles. This study aimed to examine the incidence and risk of shingles in adults with pSS and pharmacological treatments. METHODS This retrospective population-based cohort study was conducted using National Health Insurance claims data. Using propensity scores, 4,287 pSS a...

We sought to determine predictors of shingles reports in adults with common variable immunodeficiency or immunoglobulin (Ig) G subclass deficiency (CVID/IgGSD). We tabulated observations at diagnosis of CVID/IgGSD in 212 white adult index patients (165 women, 47 men) who responded to a question about having had shingles. None had been vaccinated for herpes zoster. We analyzed age, sex, and shin...

US transportation agencies have been increasingly using recycled asphalt shingles (RAS) in hot mix asphalt (HMA) applications over the last 25 years. Initial use of RAS started with recycled postmanufacturers shingles, but now agencies are showing a growing interest in using post-consumer (tear-off) RAS in asphalt applications. Post-consumer asphalt shingles typically have 20 to 30 percent asph...

US transportation agencies have been increasingly using recycled asphalt shingles (RAS) in hot mix asphalt (HMA) applications over the last 25 years. Initial use of RAS started with recycled postmanufacturers shingles, but now agencies are showing a growing interest in using post-consumer (tear-off) RAS in asphalt applications. Post-consumer asphalt shingles typically have 20 to 30 percent asph...

Little is known about why some patients with shingles are admitted to hospital. We reviewed 72 case notes from a list of 80 patients admitted to hospital with shingles over a six-year period. Pain was the main complaint of the patients admitted, most of whom were elderly and lived alone. The commonest site of involvement in hospital admissions was the eye (herpes zoster ophthalmicus). Diagnosis...