Alkannin/shikonin (±)-5, 8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone), also known as Shikalkin, is a racemic mixture of naturally occurring isohexenylnaphthazarin compounds. The (S) isomer is called as alkannin and (R) isomer is called as shikonin. Study was undertaken with an objective to develop a method for isolation of shikalkin from roots of Arnebia nobilis Reichb.f. b...

In pursuit of strong shikalkin-producing cell lines, seeds of the Iranian Arnebia euchroma were collected from Dena altitudes in the central Zagross. Chemical analysis showed that the dried root of the plant contained about 8.5% (w/w) shikalkin pigment. The root explants of the young plantlets, obtained from the germinated seeds, were used for establishing callus. Then, parameters effective on ...

Background: There is a growing demand for mass production of shikalkin (a natural pigment consisted of shikonin and alkannin) due to its increasing applications in cosmetics, pharmaceutical and nutrition industries. The root of Iranian Arnebia euchroma produces shikalkin. The promising capability of this plant for shikalkin production has already been demonstrated in cell culture studies. Obje...

background: there is a growing demand for mass production of shikalkin (a natural pigment consisted of shikonin and alkannin) due to its increasing applications in cosmetics, pharmaceutical and nutrition industries. the root of iranian arnebia euchroma produces shikalkin. the promising capability of this plant for shikalkin production has already been demonstrated in cell culture studies. objec...

arnebia pulchra (willd. ex roem. & schult.) edm. is an endangered, perennial member of boraginaceae family. spectrophotometric and lc-mass analysis confirmed the existence of shikalkin derivatives in its root skin and polyphenolic compounds in the inner part of its root. studies on the regeneration of a. pulchra from its callus resulted in successful callus induction in the root explants excise...

Arnebia pulchra (Willd. ex Roem. & Schult.) Edm. is an endangered, perennial member of Boraginaceae family. Spectrophotometric and LC-Mass analysis confirmed the existence of shikalkin derivatives in its root skin and polyphenolic compounds in the inner part of its root. Studies on the regeneration of A. pulchra from its callus resulted in successful callus induction in the root explants excise...