background: about 5–10% of patients with asthma suffer from poorly-controlled disease despite corticosteroid (cs) therapy. methods: 21 severe and 30 mild asthma patients were recruited and underwent collection of blood sample. we determined whether there were any differences in inflammatory biomarkers between severe and mild asthma patients or not.results: levels of interleukin-8 (il-8) and int...

purpose: to determine the anatomical sites and causes of severe visual impairment (svi) and blindness in children attending a school for the blind in ahvaz. methods: in this case series study, all 51 students of the only school for the blind in ahvaz were examined by two ophthalmologists. blindness and svi were defined according to the world health organization (who) criteria as visual acuity l...

severe thrombocytopenia with bleeding is rarely reported in children with brucellosis, and recurrent epistaxis is extremely rare. brucellosis with hemorrhage should be differentiated from viral hemorrhagic fever, malignancy, and other blood disorders. bone marrow aspiration (bma) is mandatory to differentiate from other blood diseases. an 8-year-old boy was admitted with recurrent epistaxis, pe...

severe  congenital  neutropenia  (scn)  is  a  rare  primary  immunodeficiency   disease. different genes are found to be associated with scn, including ela2, hax1, was, gfi1, g-csfr  and  g6pc3.  the  aim  of  this  study  was  to  find  different  gene  mutations responsible for scn in iranian patients. twenty-seven   patients   with   scn  referred   to  immunology,   asthma   and  allergy r...

severe congenital neutropenia (scn) is a rare primary immunodeficiency. different genes are found to be associated with scn, including ela2, hax1, was, gfi1, g-csfr. also, recently g6pc3 as a rare gene in scn has been reported. patients with g6pc3 often have cardiac and/or urogenital malformations. two patients with   persistent   severe   neutropenia,   recurrent   infections   and   maturatio...

scid disorder is major failure of the immune system, usually genetic. the aim of this study was on mutations detection of rag1, rag2, and il7rg genes in scid cases. mutation detection was performed by pcr sequencing. our results  indicated  that 13  mutations  were found  through  cases which  include 4 mutations in il7r gene (t661i, i138v, t56a, c57w), 7 mutations in rag1 (w896x, w204r, m324v,...

though intravenous (iv) magnesium sulphate (mgs04) has additive effect to beta-2 agonists, its additive benefit in face of combination therapy with beta-2-agonists and ipratropium (standard therapy of severe acute exacerbation of asthma) remains unaddressed. the aim of this investigation was to evaluate the role of iv mgso4 when used as an adjunct to standard therapy of severe exacerbations of ...

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main goal in the management of patients with severe traumatic brain injury (tbi) is control of intracranial pressure (icp). decompressive craniectomy is an accepted technique for control of refractory intracranial hypertension in patients with severe tbi. because of high complication rate after decompressive craniectomy, new techniques such as basal cisternostomy have developed. we herein repor...