نتایج جستجو برای: Sesamol

تعداد نتایج: 171  

Journal: :Biochimie 2013
R M Thushara M Hemshekhar K Sunitha M S Kumar S Naveen K Kemparaju K S Girish

Platelets play an indispensable role in human health and disease. Platelets are very sensitive to oxidative stress, as it leads to the damage of mitochondrial DNA, which is the initial step of a sequence of events culminating in the cell death through the intrinsic pathway of apoptosis. Owing to a lot of reports on secondary complications arising from oxidative stress caused by therapeutic drug...

Journal: :European journal of nutrition 2013
Mahadevappa Hemshekhar Ram Mohan Thushara Sadashivaiah Jnaneshwari Sannaningaiah Devaraja Kempaiah Kemparaju Kesturu Subbaiah Girish

PURPOSE The dietary sesamol is one of the important constituent of sesame seed that has been mainly claimed to combat cardiovascular disease and diabetes, which are the major secondary complications of arthritis. Thus, the present study was designed to evaluate the anti-arthritic, anti-inflammatory and anti-stress potentials of sesamol. METHODS Arthritis was induced using Freund's complete ad...

2015
Seung‐hwa Baek Sang‐Han Lee

The development of antimelanogenic agents is important for the prevention of serious aesthetic problems such as melasma, freckles, age spots and chloasma. The aim of this study was to investigate the antimelanogenic effect of sesamol, an active lignan isolated from Sesamum indicum, in melan-a cells. Sesamol strongly inhibited melanin biosynthesis and the activity of intracellular tyrosinase by ...

2015
Srinivasan Periasamy Pei-Yi Chu Ya-Hui Li Dur-Zong Hsu Ming-Yie Liu

Sepsis is one of the major causes of death reported in intensive care units. Acute kidney injury (AKI) and hypotension are important in the pathogenesis and mortality of systemic inflammatory response (SIR). Sesamol delays mortality in sepsis; however, its effects on AKI and hypotension and the role of peroxisome proliferator-activated receptor-ɣ (PPAR-γ) activation have not been established. W...

2017
Zhigang Liu Bo Ren Yihui Wang Chen Zou Qinglian Qiao Zhijun Diao Yashi Mi Di Zhu Xuebo Liu

Sesamol, a nutritional phenolic antioxidant compound enriched in sesame seeds, has been shown to have potential anticancer activities. This study aims at characterizing the antitumor efficacy of sesamol and unveiling the importance of mitochondria in sesamol-induced effects using a human hepatocellular carcinoma cell line, HepG2 cells. Results of this study showed that sesamol treatment suppres...

2017
Burak Turgut İrfan Ergen Nevin İlhan

Objectives To investigate the potential protective effects of sesamol in an experimental cataract model. Materials and Methods Twenty-one Spraque Dawley rat pups were randomly assigned into three groups, seven rats in each. All the rats except for those in the control group were injected subcutaneously with a single dose of sodium selenite on postpartum day 9. On days 10-14, rats in the sham ...

2015
Srinivasan Periasamy Pei-Yi Chu Ya-Hui Li Dur-Zong Hsu Ming-Yie Liu

Sepsis is one of the major causes of death reported in intensive care units. Acute kidney injury (AKI) and hypotension are important in the pathogenesis and mortality of systemic inflammatory response (SIR). Sesamol delays mortality in sepsis; however, its effects on AKI and hypotension and the role of peroxisome proliferatoractivated receptor-γ (PPAR-γ) activation have not been established. We...

2013
Dur-Zong Hsu Yi-Wei Chen Pei-Yi Chu Srinivasan Periasamy Ming-Yie Liu

Stress-related mucosal disease (SRMD) causes considerable morbidity and mortality in critically ill patients. 3,4-Methylenedioxyphenol (sesamol) has been reported to have potent antioxidative and anti-inflammatory properties. The aim of this study was to investigate the effect of sesamol on water immersion restraint- (WIR-) induced SRMD in rats. Rat gastric ulcer and hemorrhage were induced by ...

Journal: :Journal of food science 2009
H A Ismail E J Lee K Y Ko H D Paik D U Ahn

Four antioxidant treatments (none, 0.05% ascorbic acid, 0.01%alpha-tocopherol + 0.01% sesamol, and 0.05% ascorbic acid + 0.01%alpha-tocopherol + 0.01% sesamol) were applied to ground beef using either mixing or spraying method. The meat samples were placed on Styrofoam trays, irradiated at 0 or 2.5 kGy, and then stored for 7 d at 4 degrees C. Color, lipid oxidation, volatiles, oxidation-reducti...

Journal: :Archives of pharmacal research 2012
Lakshmanan Vennila Kodukkur Viswanathan Pugalendi

Myocardial infarction is the leading cause of death all over the world. Sesamol is a potent phenolic antioxidant contained only in processed sesame oil and possesses potent chemopreventive, antimutagenic, antihepatotoxic and antioxidation properties. This study was undertaken to investigate the effect of sesamol on plasma and tissue lipid profiles in isoproterenol (ISO) - induced rats. Myocardi...

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