humans suffer transient or persistent starvation due to a lack of food intake, either because of fasting, voluntary dieting, or due to the scarcity of available food. at the cellular level it is possible to possess pathological starvation during ischemia and solid tumors. blood provides many nutrients to our cells, and researchers provide these nutrients to cells in culture in the form of enric...

cancer treatment is still of the greatest challenges that health care providers and patients are facing. one of the unsolved problems in cancer treatment is cells’ reaction to metabolic stress caused by harsh nutritional conditions around tumor. in order to be able to treat this disease properly, it is important to understand the true nature of the disease. in fact, the cells inside the central...

fibroblasts could be considered as connective tissue cells that are morphologically heterogeneous with diverse functions depending on their location and activity. these cells play critical role in health and disease such as cancer and wound by production of collagen, fibronectin, cytokines and growth factors. absence of insulin and other growth factors in serum deprivation condition and similar...

  Humans suffer transient or persistent starvation due to a lack of food intake, either because of fasting, voluntary dieting, or due to the scarcity of available food. At the cellular level it is possible to possess pathological starvation during ischemia and solid tumors. Blood provides many nutrients to our cells, and researchers provide these nutrients to cells in culture in the form of en...

The epidermis is a spatially arranged tissue of different keratinocytes consisting stem cells, proliferating and differentiating cells. However, the mechanisms regulators arrangement remain unknown. Here, we show that serum starvation induces spontaneous pattern formation in keratinocytes.When were cultured beyond confluence, areas with densely clustered cells those sparsely distributed appeare...

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor important for colon cancer neovascularization. In previous studies, serum starvation led to induction of VEGF in human colon carcinoma cells. We investigated the possible participation of mitogen-activated protein kinases in serum starvation induction of VEGF in the HT29 human colon carcinoma cell line. The extracellular si...

Hepatitis C virus (HCV) core protein either enhances or inhibits apoptosis depending on the apoptosis-inducing stimuli and cell conditions. In this paper we studied possible effect of HCV core protein on apoptosis induced by serum starvation. NIH3T3 cells stably expressing HCV core protein were more resistant to serum starvation-induced apoptosis than were the non-expressing control. Neither p5...

The effects of starvation and subsequent re-feeding on compensatory growth performance, blood serum metabolites and IGF-ImRNA expression in liver and muscle were investigated in juvenile Persian sturgeon. Growth indices including body weight, SGR, CF, and HSI significantly decreased after starvation. However, after re-feeding sturgeons that were starved for 1 week reached the same weight as the...