objective(s):  the aim of this study was to evaluate the final outcome of nerve regeneration across the eggsell membrane (esm) tube conduit in comparison with autograft. materials and methods: thirty adult male rats (250-300 g) were randomized into (1) esm conduit, (2) autograft, and (3) sham surgery groups. the eggs submerged in 5% acetic acid. the decalcifying membranes were cut into four pie...

background: initial studies have shown that low-energy ultrasound stimulates living tissue cells to reduce regeneration or speed up their recovery. the purpose of this study was to examine the effects of various ultrasound parameters on the speed of recovery in injured sciatic nerves. methods: nmri mice (n = 200) with injured left paw, caused by crushing their sciatic nerves, were randomly sele...

objective: to assess the effect of heparin binding neurotrophic factor (hbnf) on sciatic nerve regeneration in animal model of rat. methods: seventy-five male wistar rats were divided into five experimental groups randomly (each group containing 15 animals): sham operation group (sham), autograft group (auto), transected control (tc), chitosan conduit (chit) and heparin binding neurotrophic fac...

to evaluate the effects of local administration of the fetal brain extract (fbe) on the crushed peripheral nerve, 15 male wistar rats were used. the right sciatic nerve of 10 rats was locally underwent the tense compression for 30 seconds and then randomly divided into experimental and control (sham) groups. the remained rats were considered as intact animals. treatment was commenced weekly, by...

gonadotropin-releasing hormone (gnrh) has neuromodulatory roles in central and peripheral nervous systems. the purpose of this study is to evaluate the effect of gnrh analog (buserelin) on peripheral nerve regeneration. forty adult male rats were divided into buserelin-treated, normal saline, sham surgery, and castrated + buserelin groups. the left sciatic nerve was crushed by a fine forceps an...

background: many people suffer from nerve injury. the time consuming nature of the treatments makes the condition worse. therefore, finding a way to accelerate the process of nerve repair is very important. objective: to determine the effect of ultrasound on the acceleration of crushed peripheral nerve regeneration. methods: the experimental model included crushed rat’s sciatic nerve. 40 rats w...

a b s t r a c tintroduction: peripheral nerve injury is a common disorder and leads to permanent neurological defects. schwann cells have been shown to have nerve repair after being transplanted in peripheral nerve injury. the aim of this study was to determine the beneficial effect of allograft schwann cells on electrophysiological outcome after transection of the sciatic nerve in rats.methods...

background: olfactory ensheathing glia (oeg) has been shown to have a neuroprotective effect after being transplanted in rats with spinal cord injury. this study was conducted to determine the possible beneficial results of olfactory mucosa transplantation (omt) which is a source of oeg on functional recovery and axonal regeneration after transection of the sciatic nerve. methods: in this study...

Autograft is gold standard treatment for peripheral nerve repair up to now. Eggshell membrane (ESM) as nerve guide channel effectively enhances nerve regeneration. Dimethyl sulphoxide (DMSO) has anti-inflammatory and anti-oxidant properties. The aim of this study was to evaluate the effect of DMSO+eggshell membrane guide channel on sciatic nerve regeneration in rats. Thirty two adult male rats ...