A simple, precise, accurate and precise reverse phase high performance liquid chromatographic method has been developed and validated for the estimation of satranidazole and gatifloxacin simultaneously in combined dosage forms. A Lichrospher 100 C-18 and mobile phase comprises of Water: Acetonitrile: Triethylamine (75:25:0.35, v/v/v) were used for separation. Final pH was adjusted to 3.2 ± 0.02...

A simple, selective, rapid and precise reverse phase HPLC method has been developed for the simultaneous estimation of Ofloxacin and Satranidazole in tablets. The analyte was resolved by using a mobile phase 0.05 M phosphate buffer and acetonitrile in the ratio of 65:35 v/v at a flow rate of 1.0 ml/min on an isocratic HPLC system at a wavelength of 320 nm. The linearity was obtained in the conc...

The extended Hildebrand solubility parameter approach is used to estimate the solubility of satranidazole in binary solvent systems. The solubility of satranidazole in various dioxane-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility of satranidazole in the binary solvent, dioxane-...

An objective of periodontal treatment is to suppress or eliminate sub gingival periodontal pathogens. Local delivery devices for periodontitis are designed to deliver the drug locally into periodontal pocket. Satranidazole is a 5-nitroimidazole derivative active against gram negative anaerobic periodontal infections. For site specific one time continuous delivery of Satranidazole, an antimicrob...

Objective: The goal in using a local nonsurgical controlled intrapocket device for the delivery of an antimicrobial agent is the achievement and maintenance of therapeutic drug concentration for the desired period of time. Methods: The study was conducted to fabricate a bio erodible delivery system for Satranidazole, dispersed in two different polymers, natural Chitosan and semi synthetic HPMC ...

The solubility of satranidazole in several water-N,N-dimethylformamide mixtures was analysed in terms of solute-solvent interactions and data were treated on the basis of extended Hildebrand solubility approach. The solubility profile of satranidazole in water-N,N-dimethylformamide mixtures shows a curve with a solubility maxima well above the ideal solubility of drug. This is attributed to sol...

Abstract Background The purpose of the present study was to evaluate layered satranidazole powder using natural polysaccharides as coating materials for colon targeting that were inexpensive and with a non-toxic nature composite response design 3 levels 2 factors each four responses in quadratic model. independent variables ratio consistency % (X1) level (X2) pellet. dependent release drug at h...

Satranidazole, a potent broad spectrum antiprotozoal, is a poorly water-soluble drug and has low bioavailability on oral administration. One of the important methods to improve the solubility and bioavailability of a less water-soluble drug is by the use of cosolvents. The solubility enhancement produced by binary blends with a cosolvent (dioxane) was studied against the solubility parameter of...

       The Extended Hildebrand Solubility Parameter Approach (EHSA) is used to estimate the solubility of satranidazole in binary solvent systems. The solubility of satranidazole in various water-PEG 400 mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility equation employs term interaction ...

the extended hildebrand solubility parameter approach (ehsa) is used to estimate the solubility of satranidazole in binary solvent systems. the solubility of satranidazole in various water-peg 400 mixtures was analyzed in terms of solute-solvent interactions using a modified version of hildebrand-scatchard treatment for regular solutions. the solubility equation employs term interaction energy ...