The development of compounds with a better antibacterial activity is highly needed. One way to achieve this by modifying the structure compound using chitosan as starting material, because its abundant natural source in Indonesia, biodegradable properties, and where free amines are present. This study aims obtain Mn(II) -Carboxymethyl Chitosan Schiff Base-Salicylaldehyde complex increase agains...

Mixed ligand octahedral Titanium(III) complexes with the tridentate salicylaldehydesemi-, thiosemiand isothiosemicarbazone and pyridine of general formula [Ti(L)(py)3]X(H2L 1 = salicylaldehyde semicarbazone,X=[TiCl3(py)] -, ClO4 .H2O, I . 0.5 I2; H2L 2 = salicylaldehyde thiosemicarbazone, X = [TiCl3(py)] ,[Ti Br3(py)] -, ClO4 . H2O, I3 -; H2L 3 = salicylaldehyde Smethylisothiosemicarbazone,X = ...

The mechanism of formation of coumarin (1) by Perkin reaction from salicylaldehyde was shown to involve exclusively a basecatalyzed intramolecular aldol-type condensation of O-acetyl salicylaldehyde (2) as an obligatory intermediate followed by dehydration. Direct evidence in support of this contention was provided by the formation of coumarin and 3-phenyl coumarin(5) as the sole products in th...

Glandular chemical defence relying on the action of salicylaldehyde is characteristic for Chrysomela leaf beetle larvae. The salicylaldehyde precursor salicin, sequestered from salicaceous host plants, is deglucosylated and the aglycon further oxidized by a salicyl alcohol oxidase (SAO) to the respective aldehyde. SAOs, key enzymes in salicin-based glandular chemical defence, were previously id...

The study discusses the possible binding of molecular oxygen to some new CoII complexes with the Schiff base ligands of the Co(Salen) type. The investigated complexes of CoII with the Schiff bases are: (bis(5-nitro-salicylaldehyde)ethylenediaminato)cobalt(II), Co(NSalen); (bis( -ethylene-salicylaldehyde)ethylenediaminato)cobalt(II), Co(EtSalen); (bis( -ethylene-3,5-diiode-salicylaldehyde)ethyle...

The switchable three-component reactions of 5-amino-3-methylisoxazole, salicylaldehyde and N-aryl-3-oxobutanamides under different conditions were studied and discussed. The unexpected influence of the aryl substituent in N-aryl-3-oxobutanamides on the behavior of the reaction was discovered. The key influence of ultrasonication and Lewis acid catalysts led to an established protocol to selecti...

The synthesis of propargylamines via A3 coupling mostly under metal-catalyzed procedures is well known. This work invented an unprecedented effect of salicylaldehyde, one of the A3 coupling partners, which could lead to the formation of propargylamine, an important pharmaceutical building block, in the absence of any metal catalyst and under mild conditions. The role of the hydroxy group in ort...

Schiff base derivatives have recently been shown to possess antimicrobial activity, and these derivatives include a limited number of salicylaldehyde hydrazones. To further explore this structure-activity relationship between salicylaldehyde hydrazones and antifungal activity, we previously synthesized and analyzed a large series of salicylaldehyde and formylpyridinetrione hydrazones for their ...

An efficient method has been developed for the salicylaldehyde ester-mediated ligation of unprotected peptides at serine (Ser) or threonine (Thr) residues. The utility of this peptide ligation approach has been demonstrated through the convergent syntheses of two therapeutic peptides--ovine-corticoliberin and Forteo--and the human erythrocyte acylphosphatase protein (∼11 kDa). The requisite pep...

The title compound, [Ni(C(9)H(9)O(3))(2)], was synthesized by the reaction of 3-ethoxy-salicylaldehyde with nickel(II) nitrate in methanol solution. The asymmetric unit onsists of two half-molecules; each Ni atom lies on a centre of symmetry. The Ni(II) ions are coordinated by four O atoms from two deprotonated 3-ethoxy-salicylaldehyde ligands in a slightly distorted square-planar coordination ...