نتایج جستجو برای: SUMO

تعداد نتایج: 3544  

Journal: :Biochemical Society transactions 2007
A C O Vertegaal

Post-translational modification of proteins by SUMOs (small ubiquitin-related modifiers) plays an important role in a wide variety of biological processes. The mammalian SUMO family includes three members, SUMO-1, SUMO-2 and SUMO-3. While target proteins are predominantly conjugated to monomeric SUMO, all three SUMO family members are able to multimerize in vitro. In cells, SUMOs have the poten...

Journal: :Ecotoxicology and Environmental Safety 2021

Metallothioneins (MTs) are low molecular weight cysteine-rich proteins that bind to metals. Owing their high cysteine (Cys) content, MTs effective mediators of heavy metal detoxification. To enhance the binding ability MT from freshwater crab Sinopotamon henanense (ShMT), sequence-based multiple sequence alignment (MSA) and structure-based docking simulation (MDS) were conducted in order identi...

2012
Magdalena J. Mazur Harrold A. van den Burg

Small Ubiquitin-like MOdifier (SUMO) is a key regulator of abiotic stress, disease resistance, and development in plants. The identification of >350 plant SUMO targets has revealed many processes modulated by SUMO and potential consequences of SUMO on its targets. Importantly, highly related proteins are SUMO-modified in plants, yeast, and metazoans. Overlapping SUMO targets include heat-shock ...

2018
Konstantin Tomanov Lilian Nehlin Ionida Ziba Andreas Bachmair

The small ubiquitin-related modifier (SUMO) conjugation apparatus usually attaches single SUMO moieties to its substrates, but SUMO chains have also been identified. To better define the biochemical requirements and characteristics of SUMO chain formation, mutations in surface-exposed Lys residues of Arabidopsis SUMO-conjugating enzyme (SCE) were tested for in vitro activity. Lys-to-Arg changes...

Journal: :The Biochemical journal 2009
Lin Nan Shen Marie-Claude Geoffroy Ellis G Jaffray Ronald T Hay

The modification of proteins by SUMO (small ubiquitin-related modifier) plays important roles in regulating the activity, stability and cellular localization of target proteins. Similar to ubiquitination, SUMO modification is a dynamic process that can be reversed by SENPs [SUMO-1/sentrin/SMT3 (suppressor of mif two 3 homologue 1)-specific peptidases]. To date, six SENPs have been discovered in...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
Lifang Jin Kexin Shen Tong Chen Wei Yu Huaiyu Zhang

BACKGROUND It has been reported that blocking small ubiquitin-like modifier (SUMO) conjugation by silencing SUMO gene remarkably decreased tumor growth in vivo. However, few studies have examined the relationship between SUMO gene silencing and gastric cancer (GC). The study aims to explore the effects of SUMO-1 gene silencing on GC cell proliferation and apoptosis. METHODS GC cells were cult...

2017
Dora Baczyk Melanie C Audette Sascha Drewlo Khrystyna Levytska John C Kingdom

BACKGROUND Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability. Functional SUMO family members identified in the human placenta include SUMO-1 to SUMO-3, which are elevated in pre-eclampsia. Whether the fourth isoform, SUMO-4, plays a role in placental development and function remains unknown. OBJECTI...

Journal: :Molecular & cellular proteomics : MCP 2005
Germán Rosas-Acosta William K Russell Adeline Deyrieux David H Russell Van G Wilson

Post-translational modification by the conjugation of small ubiquitin-like modifiers is an essential mechanism to affect protein function. Currently, only a limited number of substrates are known for most of these modifiers, thus limiting our knowledge of their role and relevance for cellular physiology. Here, we report the development of a universal strategy for proteomic studies of ubiquitin-...

Journal: :American journal of physiology. Endocrinology and metabolism 2006
Margarita Vigodner Tomomoto Ishikawa Peter N Schlegel Patricia L Morris

Sumoylation affects multiple cellular events, including chromatin inactivation and transcriptional repression. Our data provide the first characterization of small ubiquitin-related modifier-1 (SUMO-1) expression during human spermatogenesis by the use of high-resolution cellular SUMO-1 bioimaging. During human meiotic prophase, SUMO-1 localizes to sex chromosomes and centromeric and pericentro...

Journal: :The Journal of biological chemistry 2004
Alfred C O Vertegaal Stephen C Ogg Ellis Jaffray Manuel S Rodriguez Ronald T Hay Jens S Andersen Matthias Mann Angus I Lamond

The SUMO family in vertebrates includes at least three distinct proteins (SUMO-1, -2, and -3) that are added as post-translational modifications to target proteins. A considerable number of SUMO-1 target proteins have been identified, but little is known about SUMO-2. A stable HeLa cell line expressing His6-tagged SUMO-2 was established and used to label and purify novel endogenous SUMO-2 targe...

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