نتایج جستجو برای: STAT3 gene
تعداد نتایج: 1150357 فیلتر نتایج به سال:
Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...
background recent studies revealed that tumor-associated macrophages (tams) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. signal transducer and activator of transcription 3 (stat3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activa...
Background and Aim: Chronic myeloid leukemia(CML) is a clonal myeloproliferative disease, characterized by BCR/ABL translocation. Using tyrosine kinase inhibitors such as Imatinib, treatment for this disease has progressed remarkably. However, resistance to tyrosine kinase inhibitor is a major obstacle. Signal transducer and activator of transcription 3(STAT3) is an important transcription fact...
Background & Aims: Endurance training has an important role in the prevention and adjuvant therapy of breast cancer. The aim of the present study was to investigate the role of endurance training on miR- 155 expression, signal transducer and activator of transcription-3 (STAT3) gene expression, and interleukin 6 (IL-6) protein in breast cancer tumor in mice. Methods: In this study, 16 female Ba...
Title: Evaluation of expression and methylation of promoter of JAK2 and STAT3 genes in lung cancer tissue and its comparison with adjacent healthy tissue in 75 people with this cancer. Objective: Lung cancer is a disease that affects lung tissue cells. It is a common cancer in the world and is one of the deadliest cancers. Molecular variations of genes have a significant effect...
background: gastric cancer (gc) is widely associated with chronic inflammation. the pro inflammatory microenvironment provides conditions that disrupt stem/progenitor cell proliferation and differentiation. the signal transducer and activator of transcription- 3 (stat3) signaling pathway is involved in inflammation and also contributes to the maintenance of embryonic stem cell (escs) pluripoten...
Signal transducer and activator of transcription 3 (STAT3) is phosphorylated on tyrosine residue 705 in response to growth factors or cytokines to form activated homodimers that drive gene expression. Because the stat3 promoter has a binding site for STAT3 dimers, the amount of STAT3 protein increases when STAT3 is activated (e.g., in response to interleukin 6). Unphosphorylated STAT1 is known ...
Background and aim: Cytokines are a large family of protein messengers. These proteins induce various cellular responses. Janus kinases (JAKs) are mediators of cytokine, activated JAKs phosphorylate signal transducers, and activators of transcription (STAT) proteins that regulate cell differentiation, proliferation, and apoptosis. Aberrant JAK/STAT signaling is involved in the oncogenesis of se...
Background and aim: Aberrant activation of diverse intracellular signaling pathways involved in differentiation, cell growth, apoptosis. These pathways include known oncogenic pathways such as Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway. The JAK/STAT signaling pathway plays an important role in many cellular functions. This pathway can be activated by variou...
IFNs selectively regulate gene expression through several signaling pathways. The present study explored the involvement of STAT3 in the IFN-induced expression of the gene encoding the CXCL11 chemokine. The CXCL11 gene was induced in IFN-sensitive Daudi cells, but not in an IFN-resistant DRST3 subline with a defective STAT3 signaling pathway. Although the IFN-stimulated gene ISG15 was induced t...
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