five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of rapistrum rugosum and their structures were assigned from 1h- and 13c-nmr spectra (dept) with 2d nmr as quercetin-3-o-α-l-rhamnopyranoside (1), quercetin-3-o-β-d-xyloside (2), quercetin, 3-o-α-l-arabinopyranoside,7-o-α-l-rhamnopyranoside (3), kaempferol 3-o-α-l-arabinopyranoside, 7-o-α-l-rham...

prostate cancer is a devastating disease for which current therapies are inadequate. various lines of evidences have suggested the 5-lipoxygenase (5-lox) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of prostate cancer. thus, search for new anti-cancer drugs targeting 5-lox and leukotriene is very essential and important. the objective of the pre...

The dominant genus of sulfate-reducing bacteria (SRB) in humans is Desulfovibrio, and quantitative PCR (QPCR) targeting the 16S rRNA gene is often used in assays. We show that the 16S rRNA gene assay overestimated SRB abundance in feces from 24 adults compared to QPCR assays using primers targeting two genes involved in SRB energy metabolism.

Prostate cancer is a devastating disease for which current therapies are inadequate. Various lines of evidences have suggested the 5-lipoxygenase (5-LOX) pathway and the leukotriene receptor pathway are potential targets for prevention or treatment of Prostate cancer. Thus, search for new anti-cancer drugs targeting 5-LOX and leukotriene is very essential and important. The objective of the pre...

Phytochemical investigations of Piper sarmentosum Roxb., yielded four compounds; three amides, identified as 3-(3’,4’,5’-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4’-methoxyphenylpropanoyl) pyrrole, N -(3-phenylpropanoyl) pyrrole and a sterol namely β -sitosterol . 3-(4’-Methoxyphenylpropanoyl) pyrrole was found for the first time in this Piper spe...

In vitro studies were carried out to evaluate the cytotoxic potential of the ethanolic and aqueous extracts of Luffa acutangula against human neuronal glioblastoma cells (U343) and human lung cancer cells (A549). Screening of these extracts was done using the brine shrimp lethality bioassay, MTT assay and SRB assay. The results showed the significant decrease of the viability of the cells in a ...

phytochemical investigations of piper sarmentosum roxb., yielded four compounds; three amides, identified as 3-(3’,4’,5’-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4’-methoxyphenylpropanoyl) pyrrole, n -(3-phenylpropanoyl) pyrrole and a sterol namely β -sitosterol . 3-(4’-methoxyphenylpropanoyl) pyrrole was found for the first time in this piper species. all chemical constituents were tested fo...

Some water bodies in the Sinos River Basin (SRB) have been suffering the effects of pollution by residential, industrial and agroindustrial wastewater. The presence of cytotoxic and genotoxic compounds could compromise the water quality and the balance of these ecosystems. In this context, the research aimed to evaluate the genotoxicity and cytotoxicity of the water at four sites along the SRB ...

gand-inducible transcription factors. They include the receptor proteins for steroids, thyroid hormone, vitamin D, and retinoids. Steroid hormone receptors are structurally related and composed of six major functional domains. Domain A/B in the NH2-terminal region of the protein is the constitutive activation 1 (AF-1). Domain C, the DNA-binding domain, is arranged in two zinc-stabilized DNA-bin...