The induction of sensory organ placodes, in particular the lens placode, represents the paradigm for induction. We show that medaka Sox3 is expressed in the neuroectoderm and in the placodes of all sensory organs prior to placode formation and subsequently in placode-derived tissues. Ectopic Sox3 expression leads to ectopic expression of Pax6 and Eya1 in embryonic ectoderm and causes ectopic le...

BACKGROUND The transcription factor sex-determining region Y-box protein 3 (SOX3) plays important roles in various types of cancer. However, its expression and function have not yet been elucidated in osteosarcoma (OS). METHODS The expression levels of SOX3 in OS tissues and OS cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis. ...

SOX3 is one of the earliest neural markers in vertebrates, playing the role in specifying neuronal fate. In this study we have established first functional link between CREB and human SOX3 gene which both have important roles in the nervous system throughout development and in the adulthood. Here we demonstrate both in vitro and in vivo that CREB binds to CRE half-site located -195 to -191 with...

Neural precursors persist throughout life in the rodent forebrain subventricular zone (SVZ) and hippocampal dentate gyrus. The regulation of persistent neural stem cells is poorly understood, in part because of the lack of neural progenitor markers. The Sox B1 subfamily of HMG-box transcription factors (Sox1-3) is expressed by precursors in the embryonic nervous system, where these factors main...

Polyalanine expansion mutations have been identified in eight transcription factors that are associated with a range of congenital disorders. While some of these mutant proteins have been shown to generate cellular aggregates in heterologous cell lines, little is known about the mechanism by which these aggregates cause disease. Here we examine the aggregation and functional properties of the t...

BACKGROUND The cerebellum plays a vital role in equilibrium, motor control, and motor learning. The discrete neural and glial fates of cerebellar cells are determined by the molecular specifications (e.g. transcription factors) of neuroprogenitor cells that are influenced by local microenvironment signals. In this study, we evaluated the expression and function of Sox3, a single-exon gene locat...

also able to show that Sox3 could interact with Groucho directly. Using cell fractionation, the interacting factors could again be seen to affect each others subcellular distribution. Sox3 and Groucho both appear in the chromatin fraction when co-expressed. The transcriptional activation activity of Sox3 was repressed after coexpressing with Groucho. Using deletions of sox3 we have mapped the g...

also able to show that Sox3 could interact with Groucho directly. Using cell fractionation, the interacting factors could again be seen to affect each others subcellular distribution. Sox3 and Groucho both appear in the chromatin fraction when co-expressed. The transcriptional activation activity of Sox3 was repressed after coexpressing with Groucho. Using deletions of sox3 we have mapped the g...

also able to show that Sox3 could interact with Groucho directly. Using cell fractionation, the interacting factors could again be seen to affect each others subcellular distribution. Sox3 and Groucho both appear in the chromatin fraction when co-expressed. The transcriptional activation activity of Sox3 was repressed after coexpressing with Groucho. Using deletions of sox3 we have mapped the g...

Background Sertoli cells located in seminiferous tubular basement membrane and surrounds different types of germ cell and they were only somatic cell type that directly contacts germ cells. These cells have Several role like support activities, nutrition of germ cells.During spermatogenesis, expression of SOX3 is necessary for differentiation of spermatogonia A. SOX3 is a transcription factor, ...