The larvae of Schistosoma mansoni invade their mammalian host by utilizing a serine protease, cercarial elastase (SmCE), to degrade macromolecular proteins in host skin. The catalytic activity of serine and cysteine proteases can be regulated after activation by serpins. SmSrpQ, one of two S. mansoni serpins found in larval secretions, is only expressed during larval development and in the earl...

Reactive oxygen species, such as H2O2, have been recognized as intracellular messengers involved in several cell functions. Here we report the activation of the tyrosine kinase pp60(src) by H2O2, a mechanism required for the activation of store-mediated Ca2+ entry (SMCE) in human platelets. Treatment of platelets with H2O2 resulted in a time- and concentration-dependent activation of pp60(src)....

BACKGROUND Clinical guidelines recommend research on sub-groups of patients with low back pain (LBP) but, to date, only few studies have been published. One sub-group of LBP is movement control impairment (MCI) and clinical tests to identify this sub-group have been developed. Also, exercises appear to be beneficial for the management of chronic LBP (CLBP), but very little is known about the ma...

The aim of this study is to produce landslide susceptibility mapping by probabilistic likelihood ratio (PLR) and spatial multi-criteria evaluation (SMCE) models based on geographic information system (GIS) in the north of Tehran metropolitan, Iran. The landslide locations in the study area were identified by interpretation of aerial photographs, satellite images, and field surveys. In order to ...

Physical coupling between inositol 1,4,5-trisphosphate (IP(3)) receptors and transient receptor potential (Trp) channels has been demonstrated in both transfected and normal cells as a candidate mechanism for the activation of store-mediated Ca(2+) entry (SMCE). We have investigated the properties of the coupling between the type II IP(3) receptor and naturally expressed human Trp1 (hTrp1) in h...

In order to address contemporary issues economics and decision sciences need to expand their empirical relevance by introducing more and more realistic (thus more complex) assumptions in their models. One of the most interesting research directions in the field of public economics is the attempt to introduce political constraints, interest groups and collusion effects explicitly (Laffont, 2000)...

In order to address contemporary issues economics and decision sciences need to expand their empirical relevance by introducing more and more realistic (thus more complex) assumptions in their models. One of the most interesting research directions in the field of public economics is the attempt to introduce political constraints, interest groups and collusion effects explicitly (J.J. Laffont, ...

We propose an algorithm called Sparse Manifold Clustering and Embedding (SMCE) for simultaneous clustering and dimensionality reduction of data lying in multiple nonlinear manifolds. Similar to most dimensionality reduction methods, SMCE finds a small neighborhood around each data point and connects each point to its neighbors with appropriate weights. The key difference is that SMCE finds both...

There is an increasing demand for a new paradigm to improve flood mitigation decision processes that calls for risk reduction strategies at several levels. This demand may gain ground only if dialogue is encouraged among different perspectives, disciplines and knowledge types. The aim of this paper is to explore new routes to improve flood mitigation decision processes. A growing body of eviden...

Kota Batu memiliki potensi terjadinya bencana yang cukup besar. Pada bulan November 2021 terjadi banjir bandang di dan memakan 7 korban jiwa . Banjir diketahui telah berdampak 5 desa Kecamatan Bumiaji, Batu. Salah satu upaya mitigasi dapat dilakukan adalah membangun flood shelter. Flood shelter merupakan bangunan tempat tinggal sementara bagi ketika tiba. Diperlukan analisis spasial untuk menen...