During development, neuronal remodeling shapes neuronal connections to establish fully mature and functional nervous systems. Our previous studies have shown that the RNA-binding factor alan shepard (shep) is an important regulator of neuronal remodeling during metamorphosis in Drosophila melanogaster, and loss of shep leads to smaller soma size and fewer neurites in a stage-dependent manner. T...

Peptidergic neurons are a group of neuronal cells that synthesize and secrete peptides to regulate a variety of biological processes. To identify genes controlling the development and function of peptidergic neurons, we conducted a screen of 545 splice-trap lines and identified 28 loci that drove expression in peptidergic neurons when crossed to a GFP reporter transgene. Among these lines, an i...

Neuroblastoma (NB) is the third most common malignancy of childhood, and outcomes for children with advanced disease remain poor; amplification of the MYCN gene portends a particularly poor prognosis. Mxi1 antagonizes N-Myc by competing for binding to Max and E-boxes. Unlike N-Myc, Mxi1 mediates transcriptional repression and suppresses cell proliferation. Mxi1 and Mxi1-0 (an alternatively tran...

We examined whether pain outcomes (pain interference, perceived pain treatment effectiveness) vary by race and then whether opioid use moderates these associations. These analyses are part of a retrospective cohort study among 3,505 black and 46,203 non-Hispanic, white Department of Veterans Affairs (VA) patients with diagnoses of chronic musculoskeletal pain who responded to the 2007 VA Survey...

background: improvement of attitudes toward breast cancer positively affects the screening behaviors of women. imagery has been shown to have a positive impact on the screening behaviors of women. aim: this study aimed to investigate the effects of breast cancer screening training based on the systematic comprehensive health education and promotion (shep) model on the attitudes and breast self-...

Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein Shep as a direct interactor of two individual components of the gypsy insulator complex in Drosophila....

BACKGROUND AND PURPOSE Epidemiologic studies have demonstrated that hypertension increases the risk of stroke, and clinical trials have shown that antihypertensive therapy reduces this risk. Incident stroke was significantly decreased by treatment in the Systolic Hypertension in Elderly Program (SHEP) Trial, but the reduction in fatal events was not statistically significant. METHODS Vital st...

We reported previously the elicitation of presumably monosynaptic evoked field potentials in the dentate gyrus of immobilized rats by stimulation of the medial septal nuclei. The septo-hippocampal pathway mediating this evoked potential (SHEP) is widely assumed to be cholinergic in nature. In order to further verify this assumption we studied the effects of muscarinic drugs on the SHEPs. Scopol...

Philip Orton,1,a Sergey Vinogradov,2,a Nickitas Georgas,1,a Alan Blumberg,1,a Ning Lin,3 Vivien Gornitz,4 Christopher Little,5 Klaus Jacob,6 and Radley Horton4 1Stevens Institute of Technology, Hoboken, NJ. 2Earth Resources Technology/National Atmospheric and Oceanic Administration, Silver Spring, MD. 3Department of Civil and Environmental Engineering, Princeton University, Princeton, NJ. 4Colu...

Background & Aim: Despite the importance of screening for early diagnosis of breast cancer, few women do it. Existence an indigenous educational model to promote health literacy is essential. This study attempted to determine the effect of breast cancer screening education based on SHEP model to Healthy volunteers on women's knowledge covered by Mashhad health centers  Methods & Materials: This...