نتایج جستجو برای: SDF-1a

تعداد نتایج: 34621  

Background: It is now well established that several environmental stress factors cause activation of p38 MAP kinase and JNK in various cell types to produce chemokines. Objective: To investigate the expression of CXC chemokines Gro/KC and SDF- 1a in rat's H4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. Methods: Hepatoma cells were maintained in MEM medium. Cel...

اسماعیلی ندیمی , علی, توکلیان فردوسیه , وحید, حسن شاهی راویز, غلام حسین, زارع رنجبر , حامد, عباسی, آرمین, وزیری نژاد , رضا,

Background and purpose: Çardiovascular diseases are the most common causes of death in Ïran as well as in the world. SDF-1a, as an effective chemokine for decreasing inflammation and injury, plays a role in angiogenesis. This study compares and evaluates serum level of this chemokine in healthy people and those with ÂMÏ (Âcute Myocardial Ïnfarction) regarding age and gender. Materials and me...

Journal: :iranian journal of immunology 0
gholamhossein hassanshahi immunology and hematology departments, medical school, rafsanjan university of medical sciences, rafsanjan, iran mohammad kazemi arababadi immunology and hematology departments, medical school, rafsanjan university of medical sciences, rafsanjan, iran alan james dickson biochemistry department, faculty of life sciences, manchester university, manchester, uk

background: it is now well established that several environmental stress factors cause activation of p38 map kinase and jnk in various cell types to produce chemokines. objective: to investigate the expression of cxc chemokines gro/kc and sdf- 1a in rat's h4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. methods: hepatoma cells were maintained in mem medium...

2005
Promil Kukreja Asim B. Abdel-Mageed Debasis Mondal Kai Liu Krishna C. Agrawal

The chemokine stromal-derived factor-1A (SDF-1A/CXCL-12) and its receptor, CXCR4, play a crucial role in adhesion and transendothelium migration (TEM) of prostate cancer cells. We tested the hypothesis that enhanced expression of CXCR4 in prostate cancer cells is dependent upon SDF-1A-mediated activation of nuclear factor-KB (NF-KB). SDF-1A increased the CXCR4 mRNA and protein expression in PC-...

2005
Linda J. Bendall Rana Baraz Julius Juarez Wei Shen Kenneth F. Bradstock

The chemokine stromal-derived factor-1A (SDF-1A) regulates leukemic cell motility and proliferation; however, the importance of these functions in the growth and dissemination of leukemia is unclear. We examined SDF-1A–mediated responses of cells from 27 cases of acute lymphoblastic leukemia (ALL). Although cells from the majority of cases showed chemotactic and proliferative responses to SDF-1...

2011
Randala Hamdan Zhichao Zhou Eugenie S. Kleinerman

Platelet-derived growth factor B (PDGF-B) and its receptor, PDGFR-b, play a critical role in pericyte maturation; however, the mechanisms by which PDGF-B is upregulated in the tumor microenvironment remain unclear. We previously showed that upregulating stromal-derived factor, SDF-1a, in VEGF165-inhibited Ewing's sarcoma tumors (TC/siVEGF7-1) induced PDGF-BmRNA expression, increased infiltratio...

2005
Sheng-Bin Peng Victoria Peek Yan Zhai Donald C. Paul Qinyuan Lou Xiaoling Xia Thomas Eessalu Wayne Kohn Shaoqing Tang

Emerging evidence shows that the stromal cell–derived factor 1 (SDF-1)/CXCR4 interaction regulates multiple cell signaling pathways and a variety of cellular functions such as cell migration, proliferation, and survival. There is little information linking the cellular functions and individual signaling pathways mediated by SDF-1 and CXCR4 in human cancer cells. In this study, we have shown tha...

Journal: :Cell 2008
Holger Knaut Alexander F. Schier

The chemokine SDF-1a and its receptor CXCR4b guide germ cell migration in zebrafish by activating downstream signaling events. Boldajipour et al. (2008) now report that a second SDF-1a receptor, CXCR7, is also required for guided migration but does not function as a signaling receptor, and instead sequesters SDF-1a. These results highlight the importance of ligand clearance during guided cell m...

2005
David Zagzag Balaji Krishnamachary Herman Yee Hiroaki Okuyama Luis Chiriboga M. Aktar Ali Jonathan Melamed Gregg L. Semenza

The genetic hallmark of hemangioblastomas and clear cellrenal cell carcinomas (CC-RCCs) is loss-of-function of the von Hippel-Lindau (VHL) tumor suppressor protein. VHL is required for oxygen-dependent degradation of hypoxiainducible factor-1A (HIF-1A). In hemangioblastomas and CC-RCCs, HIF-1A is constitutively overexpressed leading to increased transcription of HIF-1–regulated genes, including...

Journal: :Cell 2008
Bijan Boldajipour Harsha Mahabaleshwar Elena Kardash Michal Reichman-Fried Heiko Blaser Sofia Minina Duncan Wilson Qiling Xu Erez Raz

Primordial germ cell (PGC) migration in zebrafish is directed by the chemokine SDF-1a that activates its receptor CXCR4b. Little is known about the molecular mechanisms controlling the distribution of this chemoattractant in vivo. We demonstrate that the activity of a second SDF-1/CXCL12 receptor, CXCR7, is crucial for proper migration of PGCs toward their targets. We show that CXCR7 functions ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید