نتایج جستجو برای: SCH23390

تعداد نتایج: 359  

Journal: :Molecular pharmacology 2002
Eldo V Kuzhikandathil Gerry S Oxford

R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) is a widely used, highly selective antagonist of D1 dopamine receptors. While investigating the crosstalk between D1 and D3 dopamine receptor signaling pathways, we discovered that in addition to being a D1 receptor antagonist, SCH23390 and related compounds inhibit G protein-coupled inwardly...

Journal: :زیست شناسی جانوری تجربی 0
محمد توشیح کارشناس ارشد فیزیولوژی انسانی، مرکز تحقیقات الکتروفیزیولوژی، دانشگاه علوم پزشکی تهران، تهران، ایران فاطمه شهبازی دکتری فیزیولوژی جانوری، دپارتمان زیست شناسی، دانشگاه پیام نور، ایران مهسا قجرزاده پزشک عمومی، دانشجوی دکتری اپیدمیولوژی، مرکز تحقیقات ضایعات مغزی- نخاعی، دانشگاه علوم پزشکی تهران، تهران، ایران نیره واحدی مزدآبادی دانشجوی کارشناسی ارشد علوم تغذیه، مرکز تحقیقات طب و داروسازی سنتی، دانشگاه علوم پزشکی تهران، تهران، ایران .

abstract injection of sulpiride (d2 receptor antagonist, antipsychotic drug) into vmn hypothalamus, increased gastric volume secretion and decreased gastric ph. the present study the effect of sch23390 (d1 dopamine receptor antagonist) on the gastric acid secretion and its acidity were studied. 70 rats were divided into 7 groups: two control groups, two sham groups given medicine solvents, a sc...

Journal: :Neuroscience research 2001
T Sawaguchi

To examine the role of dopamine receptors in the memory field of neurons for visuospatial working memory in the prefrontal cortex (PFC), dopamine and its antagonists (SCH23390 for the D1-antagonist and sulpiride for the D2-antagonist) were applied iontophoretically to neurons of the dorsolateral PFC in monkeys that performed an oculomotor delayed-response task. In this task, the subject made a ...

Journal: :Neuroscience 2013
Q Lian B Wang W Zhou S Jin L Xu Q Huang M Lai K Lu L Tang H Zhu H Lin F Zhang H Cao J Li J-F Chen R-S Ge

As a widely used intravenous short-acting anesthetic, propofol is recently indicated by clinical and animal studies for its abuse potential, but the mechanism underlying propofol abuse is largely unknown. This study examined the contribution of dopamine receptor subtype (D1 and D2 receptors) and neuroanatomical locus (i.e. nuclear accumbens) in the maintenance of propofol self-administration in...

Journal: :Journal of neurophysiology 1997
T Sawaguchi

To examine the role of dopamine receptors in the function of the premotor cortex (PM) for preparing for reaching movements, dopamine antagonists (SCH23390 for D1 receptors and sulpiride for D2 receptors) were applied iontophoretically to neurons of the PM of monkeys that performed a delayed-reaching (DR) task with their arms. In the DR task, the monkey made a reaching movement to one of three t...

2000
T. Sawaguchi

Like the striatum, the frontal motor cortices receive dopaminergic ®bers from midbrain dopamine cells and contain high levels of dopamine receptors. Among frontal cortical areas, the dorsolateral PFC (PFd1) and the dorsal premotor cortex (PMd) have strong neural connections and play a major role for working memory-guided directional movements. To reveal the role of dopamine in this cognitive mo...

Journal: :European journal of pharmacology 2011
Yoriko Akimoto Mitsuhiro Furuse

To clarify the mechanisms by which compound 48/80 (C48/80) induces scratching behavior, the involvement of dopamine D(1) receptors was investigated. The intracisternal (i.t.) administration of SCH23390 (1.0 μg), a selective dopamine D(1) receptor antagonist, significantly decreased C48/80-induced scratching behavior in mice. These results suggest that dopamine D(1) receptors contribute to scrat...

Journal: :Journal of neurophysiology 2009
Xin Feng Victor M Henriquez Judith R Walters Christy L Ludlow

Hypophonia is an early symptom in Parkinson's disease (PD) that involves an increase in laryngeal muscle activity, interfering with voice production. Our aim was to use an animal model to better understand the role of different dopamine receptor subtypes in the control of laryngeal neurophysiology. First, we evaluated the combined effects of SCH23390-a D(1) receptor antagonist with a D(2) recep...

Journal: :Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007
Zeng-Jin Yang Michel Torbey Xiaoling Li Jennifer Bernardy W Christopher Golden Lee J Martin Raymond C Koehler

Dopamine receptors regulate glutamatergic neurotransmission and Na(+),K(+)-ATPase via protein kinase A (PKA) and dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32)-dependent signaling. Consequently, dopamine receptor activation may modulate neonatal hypoxic-ischemic (H-I) neuronal damage in the selectively vulnerable putamen enriched with dopaminergic receptors. Piglets subjected ...

Journal: :Archives of Iranian medicine 2006
Soheila Fazli-Tabaei Mohammad Fahim Ali Khoshbaten

BACKGROUND/OBJECTIVE In the present study, the effect of acute lead exposure in the presence and absence of dopamine or alpha (alpha)-adrenoceptor agents on contractile response of rat isolated thoracic aorta was studied. METHODS Male Wistar rats were used in all experiments. Thoracic aorta was carefully removed, cleaned, and cut into 2-mm thick rings. The rings were mounted for measurement o...

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