Pancreatic cancer remains a disease that is very difficult to treat. S100 proteins are small calcium binding with diverse intra- and extracellular functions modulate different aspects of tumorigenesis, including tumor growth metastasis. High mobility group box 1 (HMGB1) protein multifaceted also actively influences the development progression tumors. In this study, we investigate possible corre...

Metastatic malignant melanoma has a wide spectrum of histopathologic patterns and often lacks melanin pigment. Without a known primary tumor, the diagnosis of metastatic malignant melanoma relies on a combination of morphology and immunohistochemical profile. Infrequently, commonly used markers for melanoma (S100, HMB45, Melan-A and Tyrosinase A) are negative. These cases pose critical diagnost...

UNLABELLED Many studies have reported increased expression of S100 A7 (psoriasin) in neoplastic lesions. Among them are studies on breast carcinoma, bladder squamous cell carcinoma, skin tumors and oral cavity squamous cell carcinoma. The expression of S100 A7 has not been described for laryngeal cancer. OBJECTIVE This study aims to identify the expression of the calcium-binding protein S100 ...

Despite a well-characterized lack of specificity, pathologists routinely employ S100 in the diagnosis of neural crest-derived tumors. Recent studies have shown that Sox10 is a reliable marker of neural crest differentiation that is consistently expressed in schwannian and melanocytic tumors. We sought to validate these results in a larger series of soft tissue neoplasms of both neural crest and...

The present study shows the histopathological and immunohistochemical aspects encountered in 49 benign tumors with neural origin diagnosed in the Pathology Department of the Emergency County Hospital of Craiova between 2000 and 2007. Histopathological criteria were used for the histopathological diagnosis, having been diagnosed 22 neurofibromas and 27 schwannomas. Histopathological examination ...

background gastrointestinal stromal tumors (gist) are the most common mesenchymal tumors of the gastrointestinal (gi) tract. they are usually c-kit positive and seen slightly more common in men. these tumors are seen in the gi tract from the esophagus to the anus with occasional invasion or metastasis. method in this retrospective study, we evaluated the prevalence of c-kit positive stromal tum...

this is the report of a mandibular neuroectodermal/ewing sarcoma in an 8-year-old male cross breed dogthat is unique because of tumor origin location. pedunculated, ulcerative, firm 6.0 × 4.0 × 5.5 cm tumor masseffaced the bone at the rostral part of the mandible and had a white-sanguineous color at cross sectionappearance. histopathologically, small round blue cell tumor was diagnosed. immunoh...

introduction the application of immunohistochemical method has resulted in marked improvement of the microscopic diagnosis of neoplasms combined with h&e; staining. although unique cellular antigens have not been found in salivary gland neoplasms, multiple less specific immunomarkers have been used and may be helpful in elucidating the role of myoepithelial differentiation in those neoplasms. t...

This is the report of a mandibular neuroectodermal/ewing sarcoma in an 8-year-old male cross breed dogthat is unique because of tumor origin location. Pedunculated, ulcerative, firm 6.0 × 4.0 × 5.5 cm tumor masseffaced the bone at the rostral part of the mandible and had a white-sanguineous color at cross sectionappearance. Histopathologically, small round blue cell tumor was diagnosed. Immunoh...