Ruta graveolens L. is an herbal plant which is traditionally used as an energizer and an anti-bleeding to heal injuries. Regarding increasing prevalence of mycotoxins and inefficiency of methods used to decrease them, it is possible to use plants metabolites to decrease mycotoxins. The antifungal effect of Ruta graveolens on Aspergillus flavus and Penicillium sp. in vitro by disk and well diffu...

An extract of Ruta graveolens was found to be cytotoxic to Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and L929 cells in culture (IC100=16 mg/ml) and also to increase the lifespan of tumour bearing animals. The extract further decreased solid tumours developing from DLA and EAC cells when given simultaneously with elongation of the lifespan of tumour-bearing animals. A home...

Ruta graveolens belonging to family Rutaceae has long been traditionally used as a medicinal plant as well as a flavoring agent in food. However, very little data are available on the toxicity of the plant. This report presents evidence on the genotoxic and clastogenic potential of an extract of Ruta graveolens and Ruta 200C, a homeopathic preparation. Various types of chromosomal aberrations w...

Medicinal plants are the wealthy source of antibacterial agents and curatives. There is an urgent need for new antimicrobial agents, so the antimicrobial activity for Ruta graveolens L. and Ficus carica Linn. Crude extracts were evaluated for its inhibitory activity against some disease causing selected microorganisms. Root extract of Ruta graveolens L gave 8 and 7 mm inhibition zone against Es...

Historically Ruta graveolens L. has been used in many countries, including Brazil, as an abortifacient. Scientists wanted to determine its effect on pregnancy. The active ingredient in Ruta graveolens was given to mice between the first and third day of pregnancy (DOP), between the fourth and sixth DOP or between the seventh and ninth DOP. The extract did not cause preimplantation embryonic los...

Ruta graveolens, Suspension Cultures, Cell-Free System, Acridone Biosynthesis, 1,3-DihydroxyN-methylacridone A cell-free extract of Ruta graveolens cell suspension cultures, strain R-20, was prepared which synthesizes 1,3-dihydroxy-N-methylacridone from N-methylanthranilic acid and malonylcoenzyme A. The reaction is strongly dependent on the presence of ATP. After adding of coenzyme A to the as...

The volatile components of the aerial parts of Ruta graveolens and Haplophyllum suaveolens, as well as of leaves of Zanthoxylum limoncello, Z. panamense and Z. setulosum have been studied by GC/MS analysis.

Ruta graveolens utilizes anthranilate synthase (AS) for the synthesis both of tryptophan in primary metabolism and acridone alkaloids in secondary metabolism. AS has been purified from plants and cell cultures of R. graveolens 670- and 1700-fold, respectively. Glutamine- and ammonia-dependent AS activities were strictly co-purified in all steps. Through cDNA cloning and complementation of Esche...

The Authors have studied the biosynthesis of some furocoumarins contained in Ruta graveolens. Labeled 5,7and 7,8-dihydroxycoumarins have been administered to the herb, however practically no incorporation of radioactivity was observed in the isolated furocoumarins. Moreover, with the aim to study in a more detailed way the role of rutaretin and marmesin, trapping experiments have been performed...

BACKGROUND The Ruta graveolens L. is currently used by the Jordanian population systemically for its antispasmodic, diuretic, sedative, and analgesic effects and externally for its antirheumatic effect. OBJECTIVE To study plant effects on the reproductive system and fertility using adult male albino rats with special emphasis on the aggressive behavior and sex behavior. The aqueous extracts o...