background and objective: parkinson’s disease (pd) is a rather common neurological disorder in elders that is due to degeneration of dopaminergic neurons within mesencephalic substantia nigra pars compacta. with regard to protective and antioxidant effect of simvastatin, this study was conducted to evaluate its neuroprotective effect in an experimental model of pd. materials and methods: in thi...

The significance of the seismic rotational components have been overlooked in the seismic evaluation of structural behavior. As researchers have measured seismic components more accurately using sensitive rotational velocity sensor, it was observed that the magnitude of rotational components is considerable and could not be neglected. Hence, some parts of seismic damage or failure of structures...

an attempt has been made to explore the general trends in the seismic response of planasymmetric structures when subjected to near-fault and far-fault ground motions. systems with structural wall elements in both orthogonal directions considering actual and common nonlinear behavior under bi-directional excitation were studied. idealized single-storey models with uni-axial eccentricity were emp...

background and objective: parkinson's disease (pd) is a neurodegenerative disease with selective damage of mesencephalic dopaminergic neurons. due to the protective, anti-inflammatory, and antioxidant effect of hypericum perforatum (hp), this study was undertaken to assess dose-dependent effect of hp hydroalcoholic extract on motor imbalance following intrastriatal injection of 6-hydroxydo...

introduction: a large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in parkinson's disease (pd). flavonoids like quercetin have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether quercetin administration at a high dose would attenuate behavioral abnormalities in e...