this review gives an overview of our recent findings and developments in research on brain mechanisms of morphine reward from studies using the place preference conditioning paradigm. intracranial place conditioning methodology has become a valuable and firmly established and very widely used tool in behavioural pharmacology and drug reward mechanisms. several studies have established that morp...

in the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. in this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. however, no positive results obtain...

This review gives an overview of our recent findings and developments in research on brain mechanisms of morphine reward from studies using the place preference conditioning paradigm. Intracranial place conditioning methodology has become a valuable and firmly established and very widely used tool in behavioural pharmacology and drug reward mechanisms. Several studies have established that morp...

This review gives an overview of our recent findings and developments in research on brain mechanisms of morphine reward from studies using the place preference conditioning paradigm. Intracranial place conditioning methodology has become a valuable and firmly established and very widely used tool in behavioural pharmacology and drug reward mechanisms. Several studies have established that morp...

In the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. In this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. However, no positive results obtain...

Ventral tegmental area (VTA) dopamine neurons play an important role in reward mechanisms of food intake, and VTA dopamine receptors exist on the terminal of glutamatergic and GABAergic neurons and regulate GABA and glutamate release. To our knowledge, there is no evidence to show that VTA D1 dopamine receptors play a role in regular chow intake. In this paper, the effect of SKF38393, a D1 rece...

Objective: Borderline personality disorder is one of the most severe psychiatric disorders. The purpose of this study was to predict distress tolerance, impulsivity and aggression based on emotional dysregulation and reward sensitivity among individuals with borderline personality disorder features. Methods: The statistical population of the present research was undergraduate students of Shahi...

From child play to scientific discovery, many activities human engage in are rewarding and of themselves. Here, we ask what makes such intrinsically rewarding. Based on the existing literature propose answer is an increased sense self-efficacy. That is, activity that one strengthens a person’s belief they can execute actions required successfully deal with prospective situations. We show this n...