Background and Aims: Retinoblastoma tumors are the most common intraocular malignancy in childhood, leading to death after two years. The Human Adenovirus (HAdV) infection could be critical in the retinoblastoma pathogenesis due to the virus and retinoblastoma 1 interactions. The objective of the current study was to investigate the possible presence of the HAdV genome in the retinoblastoma pat...

purpose : retinoblastoma (rb) is a relatively common childhood tumor. in this report we discuss the clinical characteristics, treatments and outcome of the treated rb patients from a referral center in iran in order to understand this medical problem in our society. methods : a retrospective study was carried out on rb cases treated in farabi eye hospital since 1979 to 2007. the variables analy...

Introduction: Retinoblastoma (RB) is a malignant retinal tumor, which affects infants and children. This cancer happens through a mutation in the retinoblastoma tumor suppressor genes (RB1). Inactivation of RB1 has been observed in more than 97% of all retinoblastoma patients with mutations. In recent years, RB treatment has developed significantly. RBchr('39')s treatment methods can be one or ...

purpose: to introduce a case of neglected advanced retinoblastoma. case report: a 6 year old girl presented with a large orbital mass enlarging over her cheek on the right side. she underwent exenteration and histopathologic evaluation. a diagnosis of retinoblastoma was made with free margins. this case presents a rare form of retinoblastoma with extensive local progression but no metastasis or...

The Retinoblastoma 1 (RB1) gene, located on chromosome 13q14 and encodes the tumor-suppressor retinoblastoma protein, is cause of Retinoblastoma. mutational inactivation both gene alleles brings this cancer. (RB) high-risk histopathological characteristics indicate metastasis or local recurrence with rapid progresses following RB1 inactivation. There growing interest in regulatory activities un...

retinoblastoma is the most common primary intraocular malignancy in childhood. enucleation remains the treatment of choice in many children because the eye can not be salvaged with any other treatment modality. in some cases after enucleation etiologies other than retinoblastoma are detected in histopathologic review (pseudoretinoblastomas). this study aims to evaluate the prevalence and etiolo...

Abstract Retinoblastoma, the most common intraocular tumor of childhood, was recently shown to comprise two major molecular subtypes. Subtype 1 includes heritable forms, with germline mutation RB1 and a cone-differentiated state. 2 is often non-hereditary, exhibits stemness features, increased expression MYCN its target genes, high risk metastasis. Relative subtype 1, tumors have worse prognosi...

in the retinoblastoma research, it is of great interest to identify molecular markers associated with the genetics of tumorigenesis. micrornas (mirnas) are small non-coding rna molecules that play a regulatory role in many crucial cellular pathways such as differentiation, cell cycle progression, and apoptosis. a body of evidences showed dysregulation of mirnas in tumor biology and many disease...