When the patient was 28 years old, he developed reticulate hyperpigmentation of the neck and upper trunk, with palmoplantar hyperkeratosis and hyperhidrosis and nail dystrophy (Fig. 1). His son (aged 8 years at the time) also began to experience similar pigmentary changes and nail dystrophy. At the time of the current referral (the patient is now 47 years old), the reticulate pigmentation had s...

When the patient was 28 years old, he developed reticulate hyperpigmentation of the neck and upper trunk, with palmoplantar hyperkeratosis and hyperhidrosis and nail dystrophy (Fig. 1). His son (aged 8 years at the time) also began to experience similar pigmentary changes and nail dystrophy. At the time of the current referral (the patient is now 47 years old), the reticulate pigmentation had s...

Reticulated pigmentation is a unique pigmentary change caused by a heterogeneous group of hereditary and acquired disorders. This pigmentation is characterized by a mottled appearance, with lesions that vary in size and pigmentary content. This review discusses the hereditary group of the reticulated pigmentation disorders, such as dyschromatosis symmetrica hereditaria, dyschromatosis universal...

DEAR EDITOR, Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP) is a rare subtype of EBS that is characterized by blistering, mottled pigmentation of the trunk and limbs, punctate hyperkeratosis of the palms and soles, and dystrophic nails. EBS-MP is caused by a mutation in the KRT5 or KRT14 gene encoding keratin 5 (K5) and keratin 14 (K14), respectively. Dermatopathia pigmentosa ...

Physical examination A reticulate hyperpigmented macular rash was present at the axillae, groins, extensor aspect of the upper limbs, buttocks, and thighs (Figure 1). Poikilodermatous changes were observed, with hypopigmented macules, epidermal atrophy and telangiectasia (Figure 2). Erythematous patches with epidermal atrophy were also seen, especially over the abdomen and chest (Figure 3). The...

Dowling Degos disease is a rare condition inherited as autosomal dominant trait characterized by numerous, asymptomatic, symmetrical, progressive, small, round-pigmented macules over axillae and groins, face, neck, arms and trunk, scattered comedo-like lesions (dark dot follicles) and pitted acneiform scars. Histopathology is diagnostic. We are hereby reporting three cases of Dowling Degos dise...

FIG. 1 Linear and Whorled Nevoid Hypermelanosis: Linear and whorled hyperpigmented macules in a reticulate pattern along the Blaschko’s lines over trunk and limbs. A two-years-old boy presented with abnormal body pigmentation and body asymmetry noted since birth. A preceding vesicular eruption was absent. He was developmentally normal. Family history was insignificant. Examination revealed line...

X-linked reticulate pigmentation disorder with systemic manifestations (XLPDR) is an extremely rare genodermatosis with recessive X-linked inheritance but unknown molecular basis. In males, cutaneous involvement is characterized by reticulate hyperpigmentation of the skin that is associated with a typical facies and severe systemic involvement. In the carrier females, manifestations are apparen...