Background and Aims : Oxacillin-resistant Staphylococcus aureus is a major pathogen causing serious infections and treatment of such infections is very difficult. Vancomycin is the last line of treatment for resistant S. aureus. The aim of this study was investigation of epidemiology of vancomycin and oxacillin resistant Staphylococcus aureus clinical isolates in Urmia   Materials and Methods...

    Background & Aims : Cefepime is one of the fourth generations of cephalosporins known to be active against a wide range of bacteria. Cefepime is usually used for treatment of infections caused by multi-drug resistant bacteria. The aim of this study was the evaluation of the effect of this antibiotic on clinical E.coli isolates.   Materials & Methods : A total of 100 isolates of E.coli were ...

Background and Objective: One of the mechanisms involved in the resistance of Klebsiella pneumoniae to fluoroquinolones is AcrAB leakage pumps.  In this study, the prevalence of Klebsiella pneumoniae isolates with AcrAB encoding genes and the role of permeation pumps in fluoroquinolone resistance were investigated. Materials and Methods: 165 samples from patients of Kermanshah Medical Centers ...

Abstract       Background and objectives: More Candida albicans strains are reported resistant to fluconazole in patients with AIDS, cancer and organ recipients. Fluconazole resistance can be attributed to changes in pathways of sterol biosynthesis, mutation in or overexpression of ERG11 and the expression of CDR1, CDR2, and MDR1. This study aimed to compare the ex...

Background and purpose: Methicillin-resistant Staphylococcus. aureus (MRSA) is specific strain of S.aureus that is a major cause of nosocomial infection. Nowadays, Vancomycin is the first-line treatment of severe MRSA infections. However, resistance to Vancomycin is reported in the form of Vancomycin-resistant Staphylococcus aureus (VRSA) too. This study aimed at determining the prevalence of M...

Background & Aims: Multiple drug resistance among Klebsiellapneumoniae isolates is one of the most important challenges for treating of such infections. Fosfomycin is a broad-spectrum peptidoglycan biosynthesis inhibitor. The purpose of this study was to evaluate the effect of fosfomycin on imipenem resistant clinical isolates of Klebsiella pneumoniae. Materials & Methods: This stud...

Background & Aims: The antimicrobial effects of nickel nanoparticles on some bacterial strains such as S. aureus and E.coli have been shown in limited studies. The aim of this study was to investigate the inhibitory effects of nickel nanoparticles on biofilm formation by mupirocin resistant S. aureus isolates. Materials & Methods: In this study, 150 S. aureus isolates were collected fro...