objective: this study aimed to evaluate the effect of seasonal variability on the assisted reproductive technique (art) success rate. materials and methods: this study was a descriptive – analytical survey performed on 91 infertile women undergoing  intracytoplasmic sperm injection – embryo transfer (icsi-et) in different seasons. the patients aged less than 35 years old and had normal lh/fsh r...

background: more and more infertile patients have accepted the assisted reproductive technique (art) therapy. concerns have been raised over an increased risk of adverse maternal outcomes in art populations as compared with natural conception (nc). objective: the aim was to improve the art in clinicial work and to reduce the incidence of pregnancy complications in art group according to analyzi...

fertilization involves direct interaction of the sperm and oocyte, fusion of the cell membranes and :union: of male and female gamete genomes. the completion of this process and subsequent embryo development depend in part on the inherent integrity of the sperm dna. sperm genome quality has been emphasized for several years as playing a major role in early embryogenesis. there is clinical evide...

backgrund: imprinted genes are a unique subset of few genes, which have been differentially methylated region (dmr) in a parental origin-dependent manner during gametogenesis, and these genes are highly protected during pre-implantation epigenetic reprogramming. several studies heve shown that the particular vulnerability of imprinting genes during suboptimal pre- and peri-conception microenvir...

background: anti-mullerian hormone (amh) levels may represent the ovarian follicular pool and could be a useful marker of ovarian reserve. the clinical application of amh measurement has been proposed in the prediction of quantitative and qualitative aspects in assisted reproductive technologies. objective: this study aimed to assess the relationship between the serum levels of amh and results ...

background: abnormal oocyte morphology has been associated with the hormonal environment to which the gametes are exposed. objective: in this study, we evaluated the oocytes morphology, fertilization rate, embryos quality, and implantation rate resulted of retrieved oocytes in different times after human chorionic gonadotrophin (hcg) administration. materials and methods: a total of 985 metapha...

Background: In the past 22 years, intracytoplasmic sperm injection (ICSI) on human oocytes become a successful method of treatment for most categories of infertility. But there are real concerns that possible malformations among ICSI infants are still not fully recognized. Despite the success of ICSI, the risk of major birth defects due to various parental factors or treatment may increase. We ...

background: detection of best predictor of ovarian reserve in patients with temporarily or consistently elevated early follicular phase serum levels of fsh is one of the most important goals in assisted reproductive technique (art). objective: to evaluate whether high level of anti-mullerian hormone level is related to success of art in patients with temporarily or consistently elevated early f...