PURPOSE Repopulation of surviving tumor cells between courses of chemotherapy might lead to effective drug resistance. Here we study inhibition of repopulation of hormone-responsive human breast cancer cell lines by selective estrogen receptor (ER) modulators (SERMs) during courses of chemotherapy. EXPERIMENTAL DESIGN Hormone responsive breast cancer cell lines MCF-7 and T47D, and the ER- cel...

This issue of Neurology ® : Neuroimmunology and Neu-roinflammation (N2) includes a wide variety of exciting articles. As usual, I had difficulty selecting the articles to highlight in this Editor's Corner, which is aimed to reflect the range of topics rather than imply a higher quality of the selected manuscripts. One of the treatments frequently used in neuro-myelitis optica (NMO) is rituximab...

Creation of bioartificial organs has been enhanced by the development of strategies involving decellularized mammalian lung. Because fibroblasts critically support lung function through a number of mechanisms, study of these cells in the context of the decellularized lung has the potential to improve the structure and function of tissue-engineered lungs. We characterized the engraftment and sur...

The experiment was designed to evaluate differences in reproductive performance parametres in sows of selected utilitarian breeds before and after repopulation. The experimental population consisted of 160 sows, while the group before repopulation counted 80 sows from 1 to 5 litter. The repopulated (newly brought) group counted 80 gilts at the 1 litter. The values of the total number of piglets...

Background: Usage of some atipycal antipsychotic drugs like sulpiride has severed effects on male fertility by impressions on sexual hormones secretion. These hormones regulate male germ cells proliferation and differentiation. In the present study we sought to elucidate the impact of sulpiride on serum prolactin and FSH concentration. Also effect of FSH on spermatogonium A/B (repopulation inde...

Tumor repopulation after radiotherapy is a big obstacle for clinical cancer therapy. The molecular mechanisms of tumor cell repopulation after radiotherapy remain unclear. This study investigated the role of sonic hedgehog (SHH) and Wnt signaling pathways in tumor repopulation after radiotherapy in an in vitro repopulation model. In this model, irradiated dying tumor cells functioned as feeder ...

OBJECTIVE To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing. METHODS Multicenter retrospective study of 16 children with NMO/NMOSD receiving ≥2 rituximab courses. According to CD19 counts, events during rituximab were categoriz...

Repopulation of tumor cells during radiotherapy is believed to be a significant cause for treatment failure. The phenomenon of tumor repopulation during fractionated radiotherapy was found from clinical observations that identified that the local control rate decreased with a prolonged treatment time. A series of animal experiments with varied overall treatment time and fractionated doses were ...

BACKGROUND Pancreatic cancer characterizes high recurrence and poor prognosis. In clinical practice, radiotherapy is widely used for pancreatic cancer treatment. However, the outcome remains undesirable due to tumor repopulation and following recurrence and metastasis after radiation. So, it is highly needed to explore the underlying molecular mechanisms and accordingly develop therapeutic stra...

The fundamental question of which genes are most important in controlling liver regeneration remains unanswered. We employed a parallel screen to test the impact of 43 selected genes on liver repopulation in the Fah(-/-) mouse model of hereditary tyrosinemia. We discovered that the transcription factor Foxa3 was a strong promoter of liver regeneration, while tumor necrosis factor receptor 1 (TN...