background: measurement of absolute or differential renal function using radiotracers plays an important role in the clinical management of various renal diseases. gamma camera quantitative methods in approximation of renal clearance may potentially be as accurate as plasma clearance methods. however some critical factors such as kidney depth and background counts are still troublesome in the u...

background: simvastatin is a widely used medication in cardiac care. here we evaluate the role of atp sensitive potassium (katp) channels in simvastatin induced renal protection after renal ischemia/reperfusion (i/r) injury.    methods: a total of 81 male wistar rats, were treated with simvastatin (10 and 20mg/kg/day gavage, one week). some groups received glibenclamide (katp channel inhibitor ...

the purpose of this study was to determine the number of prescribed antibiotics being appropriately adjusted and to assess antibiotics with the highest incorrect dosing based on the patient’s renal function according to distinguished guidelines. the study was conducted at a 446-bed university hospital. one hundred and fifty patients admitted through different wards of the hospital were included...

Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF).  ET has a potent vasoconstrictor effect, through binding with its ETA receptors, and may play some roles in renal hemodynamic dysfunction in ARF.Objective: To examine the beneficial effect of a selective ETA-receptor antagonist on renal dysfunction and tis...

Background: Measurement of absolute or differential renal function using radiotracers plays an important role in the clinical management of various renal diseases. Gamma camera quantitative methods in approximation of renal clearance may potentially be as accurate as plasma clearance methods. However some critical factors such as kidney depth and background counts are still troublesome in...

Introduction: Orexins are novel neuropeptides that are localized in neurons in the lateral hypothalamus. They are implicated in a wide variety of physiological functions. Orexin peptides and receptors are found in many peripheral organs such as kidneys. It has been demonstrated that exogenous orexin-A can induce protective effects against ischemia–reperfusion injury in many organs. The goal ...

background: previous studies have shown increases in endothelin (et) concentration of plasma and renal tissues in acute renal failure (arf).  et has a potent vasoconstrictor effect, through binding with its et a receptors, and may play some roles in renal hemodynamic dysfunction in arf. objective: to examine the beneficial effect of a selective et a -receptor antagonist on renal dysfunction and...

Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectom...

The present study was aimed to evaluate the beneficial effect of Cystone syrup in an experimental model of glycerol-induced acute renal failure (ARF) in rats. Biochemical parameters, kidney weight and histopathological evaluation were performed to conclude the beneficial effect of Cystone syrup. Administration of single dose of 50% v/v glycerol (8ml/kg.i.m) caused severe renal dysfunction assoc...