saffron, crocus sativus l. (c. sativus) is rich in carotenoids and used in traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma and cardiovascular disorders. these therapeutic effects of the plant are suggested to be due to its relaxant effect on smooth muscles. the effect of c. sativus and its constituents on different smooth muscles an...

in the previous studies the relaxant, anti-cholinergic (functional antagonism) and anti-histaminic effects of nigella sativa have been demonstrated on guinea pig tracheal chains. to elucidate the main substance responsible for the relaxant effect of this plant, the effect of thymoquinone, one of the main constituent of nigella sativa was examined in this study. the bronchodilatory effects of th...

objective(s): in regard to the high incidence of asthma and the side-effects of the drugs used, finding novel treatments for this disease is necessary. our previous studies demonstrated the preventive effect of nigella sativa extract on ovalbumin-induced asthma. in addition, water-soluble substances of n. sativa extract and methanol fraction of this plant were responsible for the relaxant effec...

objective in previous studies, the relaxant, anticholinergic (functional antagonism), antihistaminic and its stimulatory effects on b-adrenoceptors of nigella sativa have been demonstrated on guinea pig tracheal chains. in the present study, the relaxant effects of hydro-ethanolic, macerated aqueous (ma) and lipid-free macerated aqueous (lfma) extract of nigella sativa on tracheal chains of gui...

our  previous  studies demonstrated  the  preventive effect  of  nigella  sativa  extract  on asthma and water-soluble substances of this extract, especially its methanol fraction were responsible for this relaxation on contracted tracheal chains of guinea pigs. for the first time, the present study has been conducted to determine the main constituents of its methanolic extract. four constituen...

nigella sativa (n. sativa) is a spice plant which has been traditionally used for culinary and medicinal purposes. different therapeutic properties including the beneficial effects on asthma and dyspnea, digestive and gynecology disorders have been described for the seeds of n. sativa. there is evidence of the relaxant effects of this plant and some of its constituents on different types of smo...

In the previous studies the relaxant, anti-cholinergic (functional antagonism) and anti-histaminic effects of Nigella sativa have been demonstrated on guinea pig tracheal chains. To elucidate the main substance responsible for the relaxant effect of this plant, the effect of thymoquinone, one of the main constituent of Nigella sativa was examined in this study. The bronchodilatory effects of th...

The relaxant effect of the methyl ester of rosuvastatin was evaluated on aortic rings from male Wistar rats (250-300 g, 6 rats for each experimental group) with and without endothelium precontracted with 1.0 µM phenylephrine. The methyl ester presented a slightly greater potency than rosuvastatin in relaxing aortic rings, with log IC50 values of -6.88 and -6.07 M, respectively. Unlike rosuvasta...

The relaxant effect of the lactone of rosuvastatin was evaluated on aortic rings from male Wistar rats (250-300 g) with and without endothelium, precontracted with 1.0 microM phenylephrine. The lactone presented a greater potency than rosuvastatin in relaxing aortic rings. Unlike rosuvastatin, the effect of its lactone was endothelium-independent. Pretreatment with either indomethacin (10 micro...

objective(s) in the present study, the differences in the relaxant effects of aqueous, ethyl acetate and n-butanol fractions of rosa damascena on tracheal smooth muscle of guinea pigs were examined. materials and methods the relaxant effects of three cumulative concentrations of each fraction (0.1, 0.2 and 0.4 g%) in comparison with saline and three cumulative concentrations of theophylline (0....