signal regulatory proteins (sirp) belong to immunoglobulin super family (igsf) and relate to integrin signaling cascades. it has been shown that sirpa is expressed in a variety of cells including myeloid cells and neurons. in the present study the expression of this igsf member in articular chondrocytes was investigated. methods: using a panel of anti-sirpalpha antibodies, immunohistochemistry,...

the biologists now face with the masses of high dimensional datasets generated from various high-throughput technologies, which are outputs of complex inter-connected biological networks at different levels driven by a number of hidden regulatory signals. so far, many computational and statistical methods such as pca and ica have been employed for computing low-dimensional or hidden representat...

understanding the genetic regulatory networks, the discovery of interactions between genes, and understanding regulatory processes in a cell at the gene level, is one of the major goals of system biology and computational biology. modeling gene regulatory networks, describing the actions of the cells at the molecular level and is used in medicine and molecular biology applications such as metab...