Purpose: To evaluate angiogenesis and reepithelization of colonic anastomoses in rats. Methods: 82 Wistar rats, divided into: young normoglycemic, old normoglycemic and hyperglycemic. Diabetes was induced with streptozotocin. Glycemia was assessed before induction, at 24 hours and after 90 days, when a colotomy and an anastomosis were performed, assessed at days 3, 7, and 14. Samples were prepa...

wounds and wound healing have always been one of the most important subjects that experimental researches were dedicated to. simvastatin has been used for long as a common lipid lowering agent which was reported to have some pleiotropic effects such as antioxidation, anti-inflammation and immunomodulation. in this study we aimed to determine the effect of simvastatin on wound healing process in...

Purpose. To report a case of severe corneal thinning secondary to dry eye treated with a tectonic Descemet stripping automated lamellar keratoplasty (DSAEK) and amniotic membrane graft. Methods. A 72-year-old man with a history of long standing diabetes mellitus type 2 and dry eye presented with 80% corneal thinning and edema on the right eye and no signs of infectious disease, initially manage...

71-year-old male with no personal events of interest was admitted to the emergency department due to a large perianal ulcer with gluteus extension of 1 month of evolution and multiple inguinoscrotal ulcers of later onset (Fig. 1). The patient denies sexual intercourse the previous months and had not consulted earlier because of shame, but due to progression of ulcers and increasing pain he went...

PURPOSE The aim of this study was to compare the effect on corneal wound healing of 3 differently manufactured blood derivatives [autologous serum (AS), platelet-rich plasma, and serum derived from plasma rich in growth factors (s-PRGF)]. METHODS Scratch wound-healing assays were performed on rabbit primary corneal epithelial cultures and human corneal epithelial cells. Additionally, mechanic...

BACKGROUND Topical preparations are a common treatment for superficial acute wounds, which at the least do not interfere with healing and ideally result in enhanced wound healing irrespective of microbial colonization. OBJECTIVE To examine the effects of a topical antimicrobial gel and its vehicle on the wound healing of standardized, superficial abrasions. METHODS Thirty-three healthy volu...

Introduction Acellular corneal matrix, with its fine biocompatibility and strength for suturing, are being developed to replace part or full thickness of diseased corneas[1]. The bioactivity of acellular corneal matrix can be modified to the purpose of permitting host tissue regeneration. AECs innoculation may produce a mimetic model of corneal epithelium, which could promote outgrowth of cells...

The clinical use of platelet-rich plasma (PRP) for a wide variety of application has been reportedly employed most prevalently in problematic wounds, maxillofacial and hemi-facial atrophy, Romberg Syndrome, and diabetic foot ulcers. To our knowledge, PRP has never been described in the enhancement of fat grafting during tissue-engineering application in vivo. The authors describe the preparatio...