Frequently, in data packages submitted for Marketing Approval to the CHMP, there is a lack of relevant head-to-head comparisons of medicinal products that could enable national authorities responsible for the approval of reimbursement to assess the Added Therapeutic Value (ASMR) of new clinical entities or line extensions of existing therapies.Indirect or mixed treatment comparisons (MTC) are m...

Promises are a standard way to formalize partial algorithms; and advice quantifies nonuniformity. For decision problems, the latter is captured in common complexity classes such as P/ poly, that is, with advice growing in size with that of the input. We advertise constant-size advice and explore its theoretical impact on the complexity of classification problems – a natural generalization of pr...

this research aims to apply a model to the study and analysis of environmental and natural resource costs created in supply chains of goods and services produced in thailand, and propose indicators for environmental problem management, caused by goods and services production, based on concepts of sustainable production and consumer behavior. the research showed that the highest environmental co...

In this paper, our objective is to assist a graphical artist throughout the creation of stylised facial animations that exhibit characters with a handdrawn look and resemble real life without mimicking it. To this end, we present a hybrid approach combining benefits from performancedriven facial animation and user-controlled 2D modelling and animation techniques. Once we capture the movement an...

This paper is about electronic services in healthcare. I begin by providing a virtual organisation model that contains four variables: connectivity, purpose, technology and boundary. Based on the model, some predictions for the stability of virtual organisations can be done. The theoretical part is followed by a real-life example of a virtual hospital. The focus is on finding and naming the fou...