background chronic hypoxia causes apoptosis of cardiac myocytes, however, energy production by anaerobic glycolysis protects myocardium against hypoxia injuries. aldolase a is a well-characterised key enzyme of the glycolysis pathway. ghrelin, a 28-amino-acid peptide, synthesizes in the stomach and has protective roles in cardiovascular systems and also affects metabolic pathways. objectives th...

objectives in order to provide a pharmacological profile for some newly synthesized dihydropyridines, we investigated their effects on the isolated rat colon segments and the isolated rat atrium contractility. the tested compounds include alkyl ester analogues of nifedipine, in which the ortho-nitrophenyl group at position 4 is replaced by 2-alkylthio-1-benzyl-5-imidazolyl substituent, and nife...

background: it has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. however, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in isch...

background and objective : sleep deprivation (sd) is caused by a host of reasons and has numerous consequences on cardiac system. in this study, we aimed to assess the preconditioning effects of acute sd on ischemia (is)-induced ventricular arrhythmias in isolated rat hearts. materials and methods : male wistar rats randomly were placed into the four groups: is-group, acute sd group, control gr...

in the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. the hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. in the control group, the hearts were perfused by normal drug free krebs-henseleit (k/h) solution t...

objective: several studies have shown that chichorium intybus l. (c. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. the aim of the present study was to investigate the effect of aqueous extra...

introduction: in the current study, protective effect of natural honey applied during ischemia/reperfusion (i/r) was studied on infarct size in ischemic heartheart. methods: ischemic hearthearts (n=8 per group) were mounted on a langendorff apparatus at constant pressure then subjected to 30 min regional ischemia followed by 120 min reperfusion. in control group, the hearts were perfused by a m...

introduction: in the present study, potential differences between the effects of l-carnitine (lc) and acetyl-lcarnitine (alc) on ischemia/reperfusion (i/r)-induced myocardial infarction size were investigated. methods: male wistar rats were randomly divided into five groups and then anesthetized by sodium pentobarbital. hearts of the animals were removed and quickly mounted on a langendorff app...

objective: rosa damascena mill l. (r. damascena) is a well-known plant with fragrant effects. several therapeutic effects of this plant on respiratory, gastrointestinal and nervous systems have been reported. it is also suggested to have beneficial effect on cardiovascular system especially blood pressure regulation. the present study was carried out to evaluate acute cardiovascular effect of h...