the aim of the present research was to study the effects of weak cation exchange resins, polacrilex with exchangeable h+ and polacrillin potassium and strong cation exchange resin sodium polystyrene sulfonate on water uptake behavior of ranitidine hydrochloride. drug resin complexes (drc) were prepared and evaluated for the percentage of moisture gain when placed in a humidity chamber at 40e2 °...

     The aim of the present research was to study the effects of weak cation exchange resins, polacrilex with exchangeable H+ and polacrillin potassium and strong cation exchange resin sodium polystyrene sulfonate on water uptake behavior of ranitidine hydrochloride. Drug resin complexes (DRC) were prepared and evaluated for the percentage of moisture gain when placed in a humidity c...

Allergic contact dermatitis caused by ranitidine is rare. Most cases of allergic contact dermatitis caused by ranitidine have been related to occupational exposure during the pharmaceutical manufacturing process (1–5). We report a case of allergic contact dermatitis caused by ranitidine hydrochloride (HCl) in a veterinary medicament. Interestingly, there have been two recent reports of allergic...

In the present study, gastro retentive microparticulate systems of ranitidine HCl were prepared by spray drying. Biocompatible polymers like Eudragit RS100, Eudragit RL100 were used in the formulation. Factorial design (2) was employed by taking drug to polymer ratio and polymer to polymer ratio as factors. FTIR and DSC studies showed that Ranitidine HCl and excipients are compatible. Scanning ...

A sensitive high-performance liquid chromatographic method for determination of ranitidine (RAN) in rabbit plasma is described. The method is based on liquid-liquid extraction, labeling with dansyl chloride and monitoring with fluorescence detector at 338nm (ex)/523nm (em). Plasma samples were extracted with diethyl ether alkalinized with 1M sodium hydroxide. Ephedrine HCl (EPH-HCl) was used as...

orally disintegrating tablets (odt) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. we focused on taste masking and formulation of ranitidine odt which disintegrates rapidly in the mouth within 60 seconds using super-disintegrants, special polymers, water soluble and even ...

PURPOSE The aim of this study was to design, formulate and physicochemically evaluate effervescent ranitidine hydrochloride (HCl) tablets since they are easily administered while the elderly and children sometimes have difficulties in swallowing oral dosage forms. METHODS Effervescent ranitidine HCl tablets were prepared in a dosage of 300 mg by fusion and direct compression methods. The powd...

Purpose: Ranitidine hydrochloride (HCl) remains an important medication for treating acid-peptic ailments such as Gastroesophageal reflux disease (GERD). The main objective of this Post Marketing Surveillance (PMS) clinical study was to test the efficacy and safety HCl in Indian patients suffering from GERD. Patients Methods: Data 2446 (1307 males; 1121 females) 21 centers across India were ana...