UNLABELLED We investigated the distribution, stability and radiotoxicity of 125I-oligodeoxyribonucleotides (125I-ODN) in human fibrosarcoma HT-1080 cells to study the radiotoxic effects of the Auger electron emitter 125I delivered to the cells by ODN. METHODS We delivered 125I-ODN into the cells via complexing with a liposomal delivery system. To assess the intracellular distribution and stab...

BACKGROUND The relationship between ERCC2 polymorphisms and the risk of radiotoxicity remains inconclusive. The aim of our study is to systematically evaluate the association between ERCC2 polymorphisms and the risk of radiotoxicity. METHODS Publications were identified through a search of the PubMed and Web of Science databases up to August 15, 2015. The pooled odds ratios (ORs) with corresp...

Time-dependent sensitivity techniques, which have been used in the past for standard reactor applications, have been adapted to calculate the impact of data uncertainties in radiotoxicity evaluations. The methodology has been applied to different strategies of radioactive waste management connected with the EFR and IFR reactor fuel cycles. Results are provided in terms of sensitivity coefficien...

Pebble bed reactors fuel elements are specially suited for withstanding very high burn-up values. This is one of the main characteristics of a transmutation fuel. The higher the burn-up achieved in the fuel, the smaller the number of reprocessing steps needed for obtaining a high transmutation rate. In this paper, a new transmutation cycle option will be introduced, based in a single pass of th...

An assessment of the radiotoxicity of spent nuclear material and the fuel handling issues associated with plutonium (Pu) or transuranics (TRU) multi-recycling in PWRs using the CORAIL assembly concept has been performed. This necessitated the development of an analytical approach to solve directly for the equilibrium state of repeated recycle, including higher actinide content. The equilibrium ...

Partitioning and transmutation (P&T) aims at making nuclear energy more sustainable from the viewpoint of the back-end of the fuel cycle by minimising the high-level waste with respect to its mass, radiotoxicity and (possibly) repository risk. P&T mainly deals with the management – i.e. transmutation and/or special conditioning and confinement – of minor actinides and fission products, but invo...

More than 0.5 million new cases of head and neck cancer are diagnosed worldwide each year, and approximately 75% of them are treated with radiation alone or in combination with other cancer treatments. A majority of patients treated with radiotherapy develop significant oral off-target effects because of the unavoidable irradiation of normal tissues. Salivary glands that lie within treatment fi...

As part of the U.S. Department of Energy Advanced Accelerator Applications Program, a systems study was conducted to evaluate the transmutation performance of advanced fuel cycle strategies. Three primary fuel cycle strategies were evaluated: dual-tier systems with plutonium separation, dual-tier systems without plutonium separation, and single-tier systems without plutonium separation. For eac...