Introduction: Bifunctional radiosensitizer agents in which nitroaromatic moieties are attached through a linker to antineoplastic moieties have demonstrated higher cytotoxicity and radiosensitizer effects than the corresponding counterparts. This study was conducted to investigate the cytotoxicity and radiosensitizer activities of 2, 4-dinitrobenzene as a radiosensitizer moiety...

The endogenous mediator of vasodilation, nitric oxide (NO), has been shown to be a potent radiosensitizer. However, the underlying mode of action for its role as a radiosensitizer - while not entirely understood - is believed to arise from increased tumor blood flow, effects on cellular respiration, on cell signaling, and on the production of reactive oxygen and nitrogen species (RONS), that ca...

introduction h istone deacetylase inhibitors (hdis), as  radiation sensitizing agents, are considered as a novel class of anti-cancer factors, which are studied in various tumor cell-lines. valproic acid (vpa) is an hdi, which is effectively used in the treatment of epilepsy, migraines, and some particular types of depression. in this study, we evaluated the effects of vpa and ionizing radiatio...

The hypoxic cell radiosensitizer RSU 1069

objective(s):cervical cancer is a malignancy that is the second most common cause of death from cancer in women throughout the world. paederus beetle (paederus fuscipes) extract (pbe), contains bioactive compounds such as pederine which has cytotoxic properties and blocks dna and protein synthesis at very low concentrations. in this investigation we tried to determine the effects co-treatment w...

We recently developed Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas (KORTUC) as a strategy to increase intratumoral oxygen concentrations and degrade antioxidant enzymes such as peroxidase and catalase. We then developed KORTUC II, which uses sodium hyaluronate containing hydrogen peroxide as a radiosensitizer. KORTUC II requires twice-weekly administration to sustain its effects, ...

One of the promises of nanoparticle (NP) carriers is the reformulation of promising therapeutics that have failed clinical development due to pharmacologic challenges. However, current nanomedicine research has been focused on the delivery of established and novel therapeutics. Here we demonstrate proof of the principle of using NPs to revive the clinical potential of abandoned compounds using ...

Fusion-positive rhabdomyosarcoma (FP-RMS) is a highly aggressive childhood malignancy which mainly treated by conventional chemotherapy, surgery and radiation therapy. Since radiotherapy associated with high burden of late side effects in pediatric patients, addition radiosensitizers would be beneficial. Here, we thought to assess the role fenretinide, potential agent for FP-RMS treatment, as r...