INTRODUCTION Application of nanoparticles as radio sensitizer is a promising field to improve efficiency of radiotherapy. METHODS This study was conducted to review nano radio sensitizers. PubMed, Ovid Medline, Science Direct, Scopus, ISI web of knowledge, and Springer databases were searched from 2000 to May 2013 to identify relevant studies. Search was restricted to English language. RESU...

Abstract This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously into poly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunc...

The cytotoxic effect of radiotherapy of cancer is limited due to commonly observed radio-resistance in the clinic. It is, therefore, necessary to develop new strategies to enhance the radiosensitivity of tumor cells by combining therapeutic drugs with optimized radiation doses to improve the treatment outcome. Over the years, research has gained momentum in studying various herbal drugs that ha...

This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system....

Objective(s): Taking advantage of high atomic number of gold nanoparticles (GNPs) in radiation dose absorbing, many in vitro and in vivo studies have been carried out on using them as radio-sensitizer. In spite of noticeable dose enhancement by GNPs at keV energies, using this energy range for radiotherapy of deep-seated tumors is outdated. The aim of the present work was to examine the effect ...

o URPOSE: Curcumin, a potential chemopreventive gent, was found to inhibit cancer cells in S/G2M hases of the cell cycle, when radiation is more ffective. The purpose of the current study was to nvestigate whether curcumin can sensitize squaous cell carcinoma (SCC) cells to the ionizing ffects of irradiation. ETHODS: Curcumin (3.5 ) was added for 48 ours to an SCC cell line prior to irradiation...

This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system....

Introduction: To increase the radiation therapy efficiency, two approaches have been employed which include increasing the dose delivery or modifying the biological response to ionizing radiation. This study aimed to modify the biological response to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Materials and Methods:</str...