نتایج جستجو برای: Rad51 expression

تعداد نتایج: 874738  

Background: Overexpression of Rad51 protein in many tumor cells has been proven to increase radioresistance and can be related to the resistance of chemosensitivity of tumor cells. This preliminary study was conducted to determine the relationship between the Rad51 expression level in nasopharyngeal carcinoma and the response of the treatment based on the measurement o...

Journal: :iranian journal of pathology 0
dian cahyanti dept. of anatomical pathology, faculty of medicine universitas indonesia/cipto mangunkusumo hospital, jakarta, indonesia lisnawati rachmadi dept. of anatomical pathology, faculty of medicine universitas indonesia/cipto mangunkusumo hospital, jakarta, indonesia vally wulani dept. of radiology, faculty of medicine universitas indonesia/cipto mangunkusumo hospital, jakarta, indonesia marlinda adham dept. of ear nose throat head and neck surgery, faculty of medicine universitas indonesia/cipto mangunkusumo hospital, jakarta, indonesia

background: overexpression of rad51 protein in many tumor cells has been proven to increase radioresistance and can be related to the resistance of chemosensitivity of tumor cells. this preliminary study was conducted to determine the relationship between the rad51 expression level in nasopharyngeal carcinoma and the response of the treatment based on the measurement of the tumor reduction. met...

A.R. Nikoofar, B. Goliaei, L. Ghamsari, M. Taghizadeh, S. Khoei,

Background: Rad51 is a protein with critical role in double strand break repair. Down-regulation of this protein has a significant effect in radiosensitivity of some cell lines like prostate carcinoma. Compared to monolayer cell culture model, the spheroids are more resistant to radiation. The aim of the current study was to determine the Rad51 protein level in DU145 spheroids, and monol...

Journal: :iranian red crescent medical journal 0
alihossein saberi department of medical genetics, faculty of medicine, ahvaz jundishapour university of medical sciences, ahvaz, ir iran ehsan khodamoradi department of radiology and nuclear medicine, paramedical school, kermanshah university of medical sciences, kermanshah, ir iran; department of radiology and nuclear medicine, paramedical school, kermanshah university of medical sciences, kermanshah, ir iran mohammad javad tahmasebi birgani department of radiology and nuclear medicine, paramedical school, kermanshah university of medical sciences, kermanshah, ir iran manoochehr makvandi department of virology, faculty of medicine, ahvaz jundishapour university of medical sciences, ahvaz, ir iran bijan noori social determinants of health research center, kurdistan university of medical sciences, sanandaj, ir iran

background rapid dose assessment using biological dosimetry methods is essential to increase the chance of survival of exposed individuals in radiation accidents. objectives we compared the expression levels of the fdxr and rad51 genes at 6 and 18 mv beam energies in human peripheral blood lymphocytes. the results of our study can be used to analyze radiation energy in biological dosimetry. con...

Journal: :iranian journal of radiation research 0
m. taghizadeh laboratory of biophysics and molecular biology, institute of biochemistry and biophysics, university of tehran, tehran, iran s. khoei department of medical physics, school of medical basic sciences, iran university of medical sciences, tehran, iran a.r. nikoofar department of radiotherapy, iran university of medical sciences, tehran, iran l. ghamsari laboratory of biophysics and molecular biology, institute of biochemistry and biophysics, university of tehran, tehran, iran b. goliaei laboratory of biophysics and molecular biology, institute of biochemistry and biophysics, university of tehran, tehran, iran

background: rad51 is a protein with critical role in double strand break repair. down-regulation of this protein has a significant effect in radiosensitivity of some cell lines like prostate carcinoma. compared to monolayer cell culture model, the spheroids are more resistant to radiation. the aim of the current study was to determine the rad51 protein level in du145 spheroids, and monolayer ce...

2015
Inbal Gazy David A. Zeevi Paul Renbaum Sharon Zeligson Lital Eini Dana Bashari Yoav Smith Amnon Lahad Michal Goldberg Doron Ginsberg Ephrat Levy-Lahad Kerstin Borgmann

Expression of RAD51, a crucial player in homologous recombination (HR) and DNA double-strand break (DSB) repair, is dysregulated in human tumors, and can contribute to genomic instability and tumor progression. To further understand RAD51 regulation we functionally characterized a long non-coding (lnc) RNA, dubbed TODRA (Transcribed in the Opposite Direction of RAD51), transcribed 69bp upstream...

2009
Takako Ishida Yoshimasa Takizawa Takashi Kainuma Jin Inoue Tsutomu Mikawa Takehiko Shibata Hidekazu Suzuki Satoshi Tashiro Hitoshi Kurumizaka

RAD51, an essential eukaryotic DNA recombinase, promotes homologous pairing and strand exchange during homologous recombination and the recombinational repair of double strand breaks. Mutations that up- or down-regulate RAD51 gene expression have been identified in several tumors, suggesting that inappropriate expression of the RAD51 activity may cause tumorigenesis. To identify chemical compou...

Journal: :Cancer research 2003
Jeffery S Russell Kristin Brady William E Burgan Michael A Cerra Kelli A Oswald Kevin Camphausen Philip J Tofilon

Rad51 is an essential component of the homologous DNA repair pathway and has been implicated as a determinant of cellular radiosensitivity. Gleevec is a relatively specific inhibitor of c-Abl, a tyrosine kinase that can play a role in the regulation Rad51. The aim of this study was to determine the effects of Gleevec on Rad51 levels and the radiosensitivity of two human glioma cell lines and a ...

2017
Yan Li Wei-ya Wang Jiang-hong Xiao Feng Xu Dian-ying Liao Li Xie Jin Wang Feng Luo

BACKGROUND Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features of CRC. METHODS We retrospectively examined the paraffin-embedded tissue samples obtained from 54 patients with CRC who had received surgic...

Journal: :Molecular cancer therapeutics 2007
Jonathan A F Hannay Juehui Liu Quan-Sheng Zhu Svetlana V Bolshakov Lan Li Peter W T Pisters Alexander J F Lazar Dihua Yu Raphael E Pollock Dina Lev

We investigated whether Rad51 overexpression plays a role in soft tissue sarcoma (STS) chemoresistance as well as the regulatory mechanisms underlying its expression. The studies reported here show that Rad51 protein is overexpressed in a large panel of human STS specimens. Human STS cell lines showed increased Rad51 protein expression, as was also observed in nude rat STS xenografts. STS cells...

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