نتایج جستجو برای: Rac1-GTP

تعداد نتایج: 20573  

Objective(s): Atorvastatin is a cholesterol-lowering agent capable of inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase. Recent studies have demonstrated new facets of atorvastatin, such as antioxidant and anti-fibrotic properties. We investigated the effect of atorvastatin on hepatic injury via the measurement of the antioxidant capacity and protein expressio...

Journal: :Advanced Healthcare Materials 2021

Ultrasonic Patches In article number 2100785 by Xue Feng and co-workers, a flexible ultrasonic patch is designed fabricated for chronic wound treatment. While the applied to damaged area of wound, it makes conversion Rac1-GDP Rac1-GTP, which can accelerate healing wound. The soft, light completely conform treatment treat effectively.

Objective(s): The study explored the neuroprotective role of Kalirin-7 (Kal-7) in Neuro-2A cells after oxygen-glucose deprivation and reperfusion (OGD/R) treatment.Materials and Methods: The study used an OGD/R model of mouse Neuro-2A neuroblastoma cells in vitro. Cells were transfected with pCAGGS-Kal-7 to up-regulating kal-7. Then cell proliferation and apoptosis were respectively analyzed by...

Journal: :The Journal of biological chemistry 2013
Pei-Wen Chen Xiaoying Jian Hye-Young Yoon Paul A Randazzo

Focal adhesions (FAs) are dynamic structures that connect the actin cytoskeleton with the extracellular matrix. At least six ADP-ribosylation factor (Arf) GTPase-activating proteins (GAPs), including ARAP2 (an Arf6 GAP), are implicated in regulation of FAs but the mechanisms for most are not well defined. Although Rac1 has been reported to function downstream of Arf6 to control membrane rufflin...

Journal: :Molecular biology of the cell 2008
Young Chan Chae Jung Hwan Kim Kyung Lock Kim Hyun Wook Kim Hye Young Lee Won Do Heo Tobias Meyer Pann-Ghill Suh Sung Ho Ryu

Small GTPase Rac is a crucial regulator of actin cytoskeletal rearrangement, and it plays an important role in cell spreading, migration, mitogenesis, phagocytosis, superoxide generation, and axonal growth. It is generally accepted that Rac activity is regulated by the guanosine triphosphate (GTP)/guanosine diphosphate (GDP) cycle. But, it is suggested that in addition to Rac-GTP loading, membr...

2017
Aniko Keller-Pinter Bettina Ughy Monika Domoki Aladar Pettko-Szandtner Tamas Letoha Jozsef Tovari Jozsef Timar Laszlo Szilak

The small GTPases of the Rho family comprising RhoA, Rac1 and Cdc42 function as molecular switches controlling several essential biochemical pathways in eukaryotic cells. Their activity is cycling between an active GTP-bound and an inactive GDP-bound conformation. The exchange of GDP to GTP is catalyzed by guanine nucleotide exchange factors (GEFs). Here we report a novel regulatory mechanism o...

Journal: :The EMBO journal 2012
Inmaculada Navarro-Lérida Sara Sánchez-Perales María Calvo Carles Rentero Yi Zheng Carlos Enrich Miguel A Del Pozo

The small GTPase Rac1 plays important roles in many processes, including cytoskeletal reorganization, cell migration, cell-cycle progression and gene expression. The initiation of Rac1 signalling requires at least two mechanisms: GTP loading via the guanosine triphosphate (GTP)/guanosine diphosphate (GDP) cycle, and targeting to cholesterol-rich liquid-ordered plasma membrane microdomains. Litt...

2012
Xosé R. Bustelo Virginia Ojeda María Barreira Vincent Sauzeau Antonio Castro-Castro

The functional cycle of the Rac1 GTPase involves a large number of steps, including post-translational processing, cytosolic sequestration by RhoGDIs, translocation to specific subcellular localizations, activation by GDP/GTP exchange, inactivation by GTP hydrolysis, and re-formation of cytosolic Rac1/RhoGDI inhibitory complexes. Here, we summarize the current knowledge about the regulation of ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Matthew J Davis Byung Hak Ha Edna C Holman Ruth Halaban Joseph Schlessinger Titus J Boggon

RAC1 is a small, Ras-related GTPase that was recently reported to harbor a recurrent UV-induced signature mutation in melanoma, resulting in substitution of P29 to serine (RAC1(P29S)), ranking this the third most frequently occurring gain-of-function mutation in melanoma. Although the Ras family GTPases are mutated in about 30% of all cancers, mutations in the Rho family GTPases have rarely bee...

2013
Matthew J. Davis Byung Hak Ha Edna C. Holman Ruth Halaban Joseph Schlessinger Titus J. Boggon

RAC1 is a small, Ras-related GTPase that was recently reported to harbor a recurrent UV-induced signature mutation in melanoma, resulting in substitution of P29 to serine (RAC1), ranking this the third most frequently occurring gain-of-function mutation in melanoma. Although the Ras family GTPases are mutated in about 30% of all cancers, mutations in the Rho family GTPases have rarely been obse...

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