eperisone hydrochloride is a skeletal muscle relaxant and paracetamol is cyclooxygenase inhibitor. these drugs in combination are used as antispasmodics. a simple, specific, precise and accurate method was developed, namely reverse phase high performance liquid chromatography for simultaneous estimation of eperisone hydrochloride and paracetamol in tablet dosage form. in rp-hplc method separati...

easily degradating and various isomeric forms of rapamycin (sirolimus) face the determination of this compound to many challenges. in this study, we developed and validated the isocratic reversed phase high performance liquid chromatographic (rp-hplc) method for rapamycin. separation was performed on a c8 column (mz, 15 × 4.6 mm, 5 µm particle size) using methanol:water (80:20 v/v) as the mobil...

a method for determination of juglone in leaves and hulls of pterocarya fraxinifolia was developed, based on rp-hplc. this compound was extracted from leaves and hulls by chloroform refluxing about 2 hours. the chloroform was evaporated under low pressure at   50 ºc to produce a dry residue. the remained materials were dissolved in acetonitrile to be used for determination of this compound. app...

We present two new methods for purifying dinosterol (4a,23,24-trimethyl-5a-cholest-22E-en-3b-ol) from sediments for the purpose of hydrogen isotope analysis via gas chromatography–isotope ratio mass spectrometry (GC–IRMS). The first method uses reversed phase-high performance liquid chromatography (RP-HPLC) to purify dinosterol from structurally similar 4a-methyl sterols that co-elute on GC ana...

migration of compounds from packaging materials is one of the most important aspects of food safety. epoxy resins have been in inner coatings of food cans since the 1960s. these resins can be produced from bisphenol-a diglycidyl ether (badge) that is also utilized as a starter. migration of potentially toxic compounds in epoxy resins used for commercial cans is a very important food safety issu...

pregabalin (prg) is a new antiepileptic drug and aceclofenac (ace) is a potent non-steroidal anti-inflammatory drug. these drugs in combination are used for treatment of partial seizures and neuropathic pains. a simple and precise assay method by rp-hplc was developed and validated for estimation of prg and ace in acenac-n tablet. analyses of commercial tablet, acenac-n were performed using jas...

low molecular weight organic acids are most predominant in apple juice among these components fumaric acid was not exceed more than 5 ppm. it was thought that the hplc is the best method of the determination of organic acids in the apple juice. in this study, chromatographic separation of organic acids of apple juice was obtained by preparing a sample and by applying them to acid phase for extr...

a simple and reliable stability-indicating rp-hplc method was developed and validated for analysis of adefovir dipivoxil (adv).the chromatographic separation was performed on a c18 column using a mixture of acetonitrile-citrate buffer (10 mm at ph 5.2) 36:64 (%v/v) as mobile phase, at a flow rate of 1.5 ml/min. detection was carried out at 260 nm and a sharp peak was obtained for adv at a reten...