experimental and epidemiological evidences implicate the involvement of oxygen derived radicals in the pathogenesis of cancer development. oxygen derived radicals are able to cause damage to membranes, mitochondria and macromolecules including proteins, lipids and dna. accumulation of dna damages has been suggested to contribute to carcinogenesis. it would, therefore, be advantageous to pinpoin...

objective: oxidative stress as a consequence of aging can induce infertility in males. in this study, we have investigated the effects of aging on sperm parameters, intra-spermatic water soluble antioxidants, reactive oxygen species (ros), and in vitro blastocyst formation. methods: we chose 5 older nmri male mice (10-12 months) and 5 younger nmri male mice (2-3 months). sperm parameters, ros, ...

rheumatoid arthritis is a disease associated with painful joints that affects approximately 1% of the population worldwide, and for which no effective cure is available. it is characterized by chronic joint inflammation and variable degrees of bone and cartilage erosion. oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. reactive oxygen species (ros) are produc...

schizophrenia is a chronic and often debilitating illness which affects about 1% of the world population. some reagents have been used to simulate schizophrenic disorders in laboratory animals, such as amphetamine and ketamine. previous studies have suggested that reactive oxygen species (ros) production, reduced levels of atp, mitochondrial dysfunction and apoptosis are involved in the pathoph...

background: it is proved that testis is sensitive to electromagnetic field (emf) and its damage results in infertility. exposure to emf induces reactive oxygen species production and affects on anti-oxidants defense mechanisms. metallothionein (mt) is a name for a group of low molecular weight (6-7 kda), sulfhydryl rich proteins. expression of mt1 and mt2 genes in testis tissue after emf exposu...

the crude methanolic extract of the seeds of celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and anti-alzheirmer (ad) activity. the extracts showed prominent dpph free radical scavenging activity, inhibiting activity of authentic peroxynitrite (onoo-) and inhibition of total reactive oxygen species (ros) generation. in dpph radical scave...

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of potentially damaging levels of reactive oxygen species (ROS), Ca(2+), etc., which must be normalized. Evidence suggests that brief mitochondrial permeability transition pore (mPTP) openings play an important physiological role maintaining healthy mitochondria homeostasis. Adaptive and maladaptive responses to r...

spermatozoa generate reactive oxygen species (ros) in physiological amounts which play a role in sperm functions during sperm capacitation acrosome reaction (ar) and oocyte fusion. in addition damaged sperm are likely to be the source of ros. the most important ros produced by human sperm are hydrogen peroxide superoxide anion and hydroxyl radicals. besides human seminal plasma and sperm posses...